Seroatlas · Human Serome Atlas

UBE3C

Ubiquitin-protein ligase E3C

Also known as: KIAA0010, KIAA10, UBE3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15386
Gene: UBE3C
Ensembl: ENSG00000009335
Chromosome: 7
Canonical length: 1083 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Lipid droplets,Cytosol

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q15386|UBE3C
     1  MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR
    61  DRKQQYSIQR SAFDRCATLS QSGGAFPIAN GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN
   121  LIKHSSLFVK QLDGSERLTC LFQIKRLMSL CCRLLQNCND DSLNVALPMR MLEVFSSENT
   181  YLPVLQDASY VVSVIEQILH YMIHNGYYRS LYLLINSKLP SSIEYSDLSR VPIAKILLEN
   241  VLKPLHFTYN SCPEGARQQV FTAFTEEFLA APFTDQIFHF IIPALADAQT VFPYEPFLNA
   301  LLLIESRCSR KSGGAPWLFY FVLTVGENYL GALSEEGLLV YLRVLQTFLS QLPVSPASAS
   361  CHDSASDSEE ESEEADKPSS PEDGRLSVSY ITEECLKKLD TKQQTNTLLN LVWRDSASEE
   421  VFTTMASVCH TLMVQHRMMV PKVRLLYSLA FNARFLRHLW FLISSMSTRM ITGSMVPLLQ
   481  VISRGSPMSF EDSSRIIPLF YLFSSLFSHS LISIHDNEFF GDPIEVVGQR QSSMMPFTLE
   541  ELIMLSRCLR DACLGIIKLA YPETKPEVRE EYITAFQSIG VTTSSEMQQC IQMEQKRWIQ
   601  LFKVITNLVK MLKSRDTRRN FCPPNHWLSE QEDIKADKVT QLYVPASRHV WRFRRMGRIG
   661  PLQSTLDVGL ESPPLSVSEE RQLAVLTELP FVVPFEERVK IFQRLIYADK QEVQGDGPFL
   721  DGINVTIRRN YIYEDAYDKL SPENEPDLKK RIRVHLLNAH GLDEAGIDGG GIFREFLNEL
   781  LKSGFNPNQG FFKTTNEGLL YPNPAAQMLV GDSFARHYYF LGRMLGKALY ENMLVELPFA
   841  GFFLSKLLGT SADVDIHHLA SLDPEVYKNL LFLKSYEDDV EELGLNFTVV NNDLGEAQVV
   901  ELKFGGKDIP VTSANRIAYI HLVADYRLNR QIRQHCLAFR QGLANVVSLE WLRMFDQQEI
   961  QVLISGAQVP ISLEDLKSFT NYSGGYSADH PVIKVFWRVV EGFTDEEKRK LLKFVTSCSR
  1021  PPLLGFKELY PAFCIHNGGS DLERLPTAST CMNLLKLPEF YDETLLRSKL LYAIECAAGF
  1081  ELS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
tongue: 55 nTPM
parathyroid gland: 34 nTPM
smooth muscle: 27 nTPM
heart muscle: 27 nTPM
esophagus: 27 nTPM

Single-cell type

myonuclei: 342 nCPM
thyrotrophs: 291 nCPM
neutrophil progenitors: 269 nCPM
distal convoluted tubule cells: 243 nCPM
lactotrophs: 223 nCPM
somatotrophs: 222 nCPM

Immune cell

MAIT T-cell: 3 nTPM
naive CD8 T-cell: 2.8 nTPM
T-reg: 2.8 nTPM
memory CD8 T-cell: 2.5 nTPM
non-classical monocyte: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM

Brain region

choroid plexus: 45 nTPM
cerebellum: 41 nTPM
thalamus: 37 nTPM
pons: 36 nTPM
medulla oblongata: 36 nTPM
white matter: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE3C.

Disease | AllUniProt

Conditions UBE3C is implicated in, by any mechanism.

Neurodevelopmental disorder with absent speech and movement and behavioral abnormalities (NEDSMB) MIM:620270

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

See cases
Neurodevelopmental disorder with absent speech and movement and behavioral abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

proteasome complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE3C as an antibody target. Whether an autoantibody or antibody against UBE3C could matter depends on whether native UBE3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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