Seroatlas · Human Serome Atlas

CCNC

Cyclin-C

Also known as: CCNC_HUMAN, CycC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P24863
Gene: CCNC
Ensembl: ENSG00000112237
Chromosome: 6
Canonical length: 283 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>P24863|CCNC
     1  MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
    61  VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA AATSVLKTRF
   121  SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV
   181  NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
   241  WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

liver: 70 nTPM
salivary gland: 66 nTPM
pancreas: 59 nTPM
thyroid gland: 57 nTPM
epididymis: 55 nTPM
kidney: 51 nTPM

Single-cell type

esophageal apical cells: 411 nCPM
cardiomyocytes: 361 nCPM
syncytiotrophoblasts: 267 nCPM
epididymal principal cells: 237 nCPM
myonuclei: 219 nCPM
epididymal efferent duct absorptive cells: 198 nCPM

Immune cell

basophil: 41 nTPM
MAIT T-cell: 40 nTPM
total PBMC: 31 nTPM
memory B-cell: 30 nTPM
T-reg: 30 nTPM
NK-cell: 28 nTPM

Brain region

choroid plexus: 52 nTPM
cerebellum: 49 nTPM
hypothalamus: 33 nTPM
cerebral cortex: 32 nTPM
white matter: 32 nTPM
hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 2.25
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNC as an antibody target. Whether an autoantibody or antibody against CCNC could matter depends on whether native CCNC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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