Seroatlas · Human Serome Atlas

MED24

Mediator of RNA polymerase II transcription subunit 24

Also known as: CRSP100, CRSP4, DRIP100, KIAA0130, MED24_HUMAN, MED5, THRAP4, TRAP100

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75448
Gene: MED24
Ensembl: ENSG00000008838
Chromosome: 17
Canonical length: 989 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

989 residues, UniProt reviewed canonical sequence.

>O75448|MED24
     1  MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLADALLEQA MIGPSPNPLI
    61  LSYLKYAISS QMVSYSSVLT AISKFDDFSR DLCVQALLDI MDMFCDRLSC HGKAEECIGL
   121  CRALLSALHW LLRCTAASAE RLREGLEAGT PAAGEKQLAM CLQRLEKTLS STKNRALLHI
   181  AKLEEASSWT AIEHSLLKLG EILANLSNPQ LRSQAEQCGT LIRSIPTMLS VHAEQMHKTG
   241  FPTVHAVILL EGTMNLTGET QSLVEQLTMV KRMQHIPTPL FVLEIWKACF VGLIESPEGT
   301  EELKWTAFTF LKIPQVLVKL KKYSHGDKDF TEDVNCAFEF LLKLTPLLDK ADQRCNCDCT
   361  NFLLQECGKQ GLLSEASVNN LMAKRKADRE HAPQQKSGEN ANIQPNIQLI LRAEPTVTNI
   421  LKTMDADHSK SPEGLLGVLG HMLSGKSLDL LLAAAAATGK LKSFARKFIN LNEFTTYGSE
   481  ESTKPASVRA LLFDISFLML CHVAQTYGSE VILSESRTGA EVPFFETWMQ TCMPEEGKIL
   541  NPDHPCFRPD STKVESLVAL LNNSSEMKLV QMKWHEACLS ISAAILEILN AWENGVLAFE
   601  SIQKITDNIK GKVCSLAVCA VAWLVAHVRM LGLDEREKSL QMIRQLAGPL FSENTLQFYN
   661  ERVVIMNSIL ERMCADVLQQ TATQIKFPST GVDTMPYWNL LPPKRPIKEV LTDIFAKVLE
   721  KGWVDSRSIH IFDTLLHMGG VYWFCNNLIK ELLKETRKEH TLRAVELLYS IFCLDMQQVT
   781  LVLLGHILPG LLTDSSKWHS LMDPPGTALA KLAVWCALSS YSSHKGQAST RQKKRHREDI
   841  EDYISLFPLD DVQPSKLMRL LSSNEDDANI LSSPTDRSMS SSLSASQLHT VNMRDPLNRV
   901  LANLFLLISS ILGSRTAGPH TQFVQWFMEE CVDCLEQGGR GSVLQFMPFT TVSELVKVSA
   961  MSSPKVVLAI TDLSLPLGRQ VAAKAIAAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MED24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 80 nTPM
cerebellum: 52 nTPM
tongue: 46 nTPM
lung: 44 nTPM
pituitary gland: 37 nTPM
ovary: 37 nTPM

Single-cell type

salivary duct cells: 275 nCPM
conjunctival goblet cells: 218 nCPM
endometrial secretory cells: 118 nCPM
fallopian secretory cells: 91 nCPM
myonuclei: 75 nCPM
breast lactating cells: 60 nCPM

Immune cell

myeloid DC: 6.8 nTPM
memory CD8 T-cell: 6.1 nTPM
eosinophil: 6 nTPM
intermediate monocyte: 6 nTPM
gdT-cell: 5.3 nTPM
total PBMC: 5.1 nTPM

Brain region

cerebral cortex: 47 nTPM
basal ganglia: 44 nTPM
hippocampal formation: 43 nTPM
midbrain: 43 nTPM
amygdala: 41 nTPM
cerebellum: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MED24.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 156 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 2.63
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mediator complex, subunit Med24,
Mediator complex subunit 24 N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MED24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MED24 as an antibody target. Whether an autoantibody or antibody against MED24 could matter depends on whether native MED24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MED24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MED24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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