Seroatlas · Human Serome Atlas

MED26

Mediator of RNA polymerase II transcription subunit 26

Also known as: CRSP7, CRSP70, MED26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95402
Gene: MED26
Ensembl: ENSG00000105085
Chromosome: 19
Canonical length: 600 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitotic chromosome

OverviewNCBI Gene

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>O95402|MED26
     1  MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV
    61  RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA TGSANGGAHN CRPEVGAAGP
   121  PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR GDQRDLGHPG PPPKVSKASH DPLVPNSSPL
   181  PTNGISGSPE SFASSLDGSG HAGPEGSRLE RDENDKHSGK IPVNAVRPHT SSPGLGKPPG
   241  PCLQPKASVL QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP
   301  SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVC WLEQPESHQR LAGPGCKAGL
   361  SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR DYTVNLDGQV AEAGVKPVRL
   421  KERKLTFDPM TRQIKPLTQK EPVRADSPVH MEQQSRTELD KQEAKASLQS PFEQTNWKEL
   481  SRNEIIQSYL SRQSSLLSSS GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL
   541  PGLTREVTQD DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MED26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
bone marrow: 10 nTPM
skeletal muscle: 6.7 nTPM
skin: 6.1 nTPM
esophagus: 5.1 nTPM
lymph node: 4.5 nTPM

Single-cell type

pdcs: 0.6 nCPM
early spermatids: 0.4 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
early primary spermatocytes: 0.2 nCPM
mast cells: 0.2 nCPM
alveolar cells type 2: 0.1 nCPM

Immune cell

plasmacytoid DC: 1.4 nTPM
basophil: 0.7 nTPM
naive B-cell: 0.7 nTPM
T-reg: 0.7 nTPM
gdT-cell: 0.5 nTPM
memory B-cell: 0.4 nTPM

Brain region

medulla oblongata: 16 nTPM
cerebellum: 15 nTPM
hypothalamus: 15 nTPM
hippocampal formation: 15 nTPM
midbrain: 15 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.88
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.69
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
Transcription factor IIS, N-terminal
TFIIS/LEDGF domain superfamily
TFIIS helical bundle-like domain
Mediator complex subunit 26, C-terminal domain
Mediator complex subunit 26, middle domain
Mediator of RNA polymerase II transcription subunit 26
Mediator complex subunit 26 C-terminal
Mediator complex subunit 26 middle domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MED26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MED26 as an antibody target. Whether an autoantibody or antibody against MED26 could matter depends on whether native MED26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MED26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MED26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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