Seroatlas · Human Serome Atlas

CDK19

Cyclin-dependent kinase 19

Also known as: bA346C16.3, CDC2L6, CDK11, CDK19_HUMAN, KIAA1028

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWU1
Gene
CDK19
Ensembl
ENSG00000155111
Chromosome
6
Canonical length
502 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q9BWU1|CDK19
     1  MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA LKQIEGTGIS
    61  MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA EHDLWHIIKF HRASKANKKP
   121  MQLPRSMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF
   181  NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED
   241  IKTSNPFHHD QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH
   301  KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ IPYPKREFLN
   361  EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ NSTQTNGTAG GAGAGVGGTG
   421  AGLQHSQDSS LNQVPPNKKP RLGPSGANSG GPVMPSDYQH SSSRLNYQSS VQGSSQSQST
   481  LGYSSSSQQS SQYHPSHQAH RY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 25 nTPM
  • spinal cord: 23 nTPM
  • basal ganglia: 22 nTPM
  • hippocampal formation: 22 nTPM
  • amygdala: 19 nTPM
  • cerebral cortex: 18 nTPM

Single-cell type

  • neutrophils: 821 nCPM
  • oligodendrocytes: 726 nCPM
  • prostatic glandular cells: 598 nCPM
  • neutrophil progenitors: 473 nCPM
  • microglia: 256 nCPM
  • monocyte progenitors: 248 nCPM

Immune cell

  • neutrophil: 4.7 nTPM
  • basophil: 2.1 nTPM
  • classical monocyte: 1.2 nTPM
  • myeloid DC: 1 nTPM
  • eosinophil: 0.9 nTPM
  • intermediate monocyte: 0.7 nTPM

Brain region

  • white matter: 77 nTPM
  • basal ganglia: 59 nTPM
  • medulla oblongata: 54 nTPM
  • thalamus: 49 nTPM
  • cerebral cortex: 47 nTPM
  • midbrain: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK19.

Disease | AllUniProt

Conditions CDK19 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 87 (DEE87) MIM:618916

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy, 87

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
3.56
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK19 as an antibody target. Whether an autoantibody or antibody against CDK19 could matter depends on whether native CDK19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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