Seroatlas · Human Serome Atlas

FKBP5

Peptidyl-prolyl cis-trans isomerase FKBP5

Also known as: FKBP5_HUMAN, FKBP51, FKBP54, P54, PPIase, Ptg-10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13451
Gene
FKBP5
Ensembl
ENSG00000096060
Chromosome
6
Canonical length
457 aa
Protein class
Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q13451|FKBP5
     1  MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK
    61  LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP
   121  KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM
   181  FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE
   241  LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM
   301  EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA
   361  QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD
   421  AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
864 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 864 nTPM
  • skeletal muscle: 833 nTPM
  • adipose tissue: 375 nTPM
  • parathyroid gland: 214 nTPM
  • thymus: 214 nTPM
  • pancreas: 189 nTPM

Single-cell type

  • neutrophils: 5,748 nCPM
  • thymic myoid cells: 3,630 nCPM
  • monocyte progenitors: 2,489 nCPM
  • thymocytes: 1,884 nCPM
  • proximal tubule cells: 1,851 nCPM
  • innate lymphoid cells: 1,778 nCPM

Immune cell

  • total PBMC: 158 nTPM
  • naive CD4 T-cell: 134 nTPM
  • myeloid DC: 108 nTPM
  • classical monocyte: 105 nTPM
  • naive CD8 T-cell: 97 nTPM
  • intermediate monocyte: 92 nTPM

Brain region

  • basal ganglia: 49 nTPM
  • white matter: 46 nTPM
  • midbrain: 44 nTPM
  • medulla oblongata: 42 nTPM
  • pons: 40 nTPM
  • thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.73
gnomAD missense Z
1.62
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP5 as an antibody target. Whether an autoantibody or antibody against FKBP5 could matter depends on whether native FKBP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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