Seroatlas · Human Serome Atlas

IFIT5

Interferon-induced protein with tetratricopeptide repeats 5

Also known as: IFIT5_HUMAN, RI58

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13325
Gene
IFIT5
Ensembl
ENSG00000152778
Chromosome
10
Canonical length
482 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables RNA binding activity and double-stranded DNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of canonical NF-kappaB signal transduction. Located in several cellular components, including IkappaB kinase complex; actin cytoskeleton; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q13325|IFIT5
     1  MSEIRKDTLK AILLELECHF TWNLLKEDID LFEVEDTIGQ QLEFLTTKSR LALYNLLAYV
    61  KHLKGQNKDA LECLEQAEEI IQQEHSDKEE VRSLVTWGNY AWVYYHMDQL EEAQKYTGKI
   121  GNVCKKLSSP SNYKLECPET DCEKGWALLK FGGKYYQKAK AAFEKALEVE PDNPEFNIGY
   181  AITVYRLDDS DREGSVKSFS LGPLRKAVTL NPDNSYIKVF LALKLQDVHA EAEGEKYIEE
   241  ILDQISSQPY VLRYAAKFYR RKNSWNKALE LLKKALEVTP TSSFLHHQMG LCYRAQMIQI
   301  KKATHNRPKG KDKLKVDELI SSAIFHFKAA MERDSMFAFA YTDLANMYAE GGQYSNAEDI
   361  FRKALRLENI TDDHKHQIHY HYGRFQEFHR KSENTAIHHY LEALKVKDRS PLRTKLTSAL
   421  KKLSTKRLCH NALDVQSLSA LGFVYKLEGE KRQAAEYYEK AQKIDPENAE FLTALCELRL
   481  SI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFIT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 22 nTPM
  • spleen: 18 nTPM
  • lung: 16 nTPM
  • bone marrow: 15 nTPM
  • cerebral cortex: 15 nTPM
  • ovary: 14 nTPM

Single-cell type

  • epididymal basal cells: 48 nCPM
  • alveolar cells type 1: 40 nCPM
  • hepatic stellate cells: 32 nCPM
  • epididymal efferent duct ciliated cells: 29 nCPM
  • decidual stromal cells: 27 nCPM
  • pericytes: 26 nCPM

Immune cell

  • neutrophil: 45 nTPM
  • non-classical monocyte: 32 nTPM
  • intermediate monocyte: 26 nTPM
  • basophil: 25 nTPM
  • memory B-cell: 22 nTPM
  • eosinophil: 19 nTPM

Brain region

  • choroid plexus: 56 nTPM
  • spinal cord: 44 nTPM
  • cerebellum: 42 nTPM
  • white matter: 37 nTPM
  • medulla oblongata: 35 nTPM
  • hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFIT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFIT5 as an antibody target. Whether an autoantibody or antibody against IFIT5 could matter depends on whether native IFIT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFIT5 is annotated at the cell surface, where native IFIT5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFIT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFIT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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