Seroatlas · Human Serome Atlas

TRPC4AP

Short transient receptor potential channel 4-associated protein

Also known as: C20orf188, dJ756N5.2, DKFZp586C1223, DKFZP727M231, PPP1R158, TP4AP_HUMAN, TRRP4AP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEL6
Gene: TRPC4AP
Ensembl: ENSG00000100991
Chromosome: 20
Canonical length: 797 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

797 residues, UniProt reviewed canonical sequence.

>Q8TEL6|TRPC4AP
     1  MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG LVRAVQFTET
    61  FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKE ISPLLSMEAM AFVTEERKLT
   121  QETTYPNTYI FDLFGGVDLL VEILMRPTIS IRGQKLKISD EMSKDCLSIL YNTCVCTEGV
   181  TKRLAEKNDF VIFLFTLMTS KKTFLQTATL IEDILGVKKE MIRLDEVPNL SSLVSNFDQQ
   241  QLANFCRILA VTISEMDTGN DDKHTLLAKN AQQKKSLSLG PSAAEINQAA LLSIPGFVER
   301  LCKLATRKVS ESTGTASFLQ ELEEWYTWLD NALVLDALMR VANEESEHNQ ASIVFPPPGA
   361  SEENGLPHTS ARTQLPQSMK IMHEIMYKLE VLYVLCVLLM GRQRNQVHRM IAEFKLIPGL
   421  NNLFDKLIWR KHSASALVLH GHNQNCDCSP DITLKIQFLR LLQSFSDHHE NKYLLLNNQE
   481  LNELSAISLK ANIPEVEAVL NTDRSLVCDG KRGLLTRLLQ VMKKEPAESS FRFWQARAVE
   541  SFLRGTTSYA DQMFLLKRGL LEHILYCIVD SECKSRDVLQ SYFDLLGELM KFNVDAFKRF
   601  NKYINTDAKF QVFLKQINSS LVDSNMLVRC VTLSLDRFEN QVDMKVAEVL SECRLLAYIS
   661  QVPTQMSFLF RLINIIHVQT LTQENVSCLN TSLVILMLAR RKERLPLYLR LLQRMEHSKK
   721  YPGFLLNNFH NLLRFWQQHY LHKDKDSTCL ENSSCISFSY WKETVSILLN PDRQSPSALV
   781  SYIEEPYMDI DRDFTEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPC4AP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 78 nTPM
bone marrow: 66 nTPM
pancreas: 62 nTPM
pituitary gland: 60 nTPM
liver: 60 nTPM
adrenal gland: 59 nTPM

Single-cell type

somatotrophs: 328 nCPM
neutrophils: 259 nCPM
lactotrophs: 224 nCPM
oligodendrocytes: 220 nCPM
adipocytes: 189 nCPM
thyrotrophs: 187 nCPM

Immune cell

eosinophil: 51 nTPM
neutrophil: 49 nTPM
myeloid DC: 40 nTPM
non-classical monocyte: 38 nTPM
intermediate monocyte: 32 nTPM
basophil: 31 nTPM

Brain region

white matter: 101 nTPM
cerebral cortex: 83 nTPM
thalamus: 80 nTPM
pons: 80 nTPM
medulla oblongata: 79 nTPM
basal ganglia: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.55
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-type fold
Short transient receptor potential channel 4-associated protein
Protein of unknown function (DUF3689)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRPC4AP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPC4AP as an antibody target. Whether an autoantibody or antibody against TRPC4AP could matter depends on whether native TRPC4AP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPC4AP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRPC4AP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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