Seroatlas · Human Serome Atlas

TNIP2

TNFAIP3-interacting protein 2

Also known as: ABIN-2, FLIP1, KLIP, MGC4289, TNIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFZ5
Gene: TNIP2
Ensembl: ENSG00000168884
Chromosome: 4
Canonical length: 429 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q8NFZ5|TNIP2
     1  MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA
    61  PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE
   121  KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR
   181  NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG
   241  LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE
   301  QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK
   361  YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL
   421  LRHVAECCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 41 nTPM
small intestine: 38 nTPM
kidney: 35 nTPM
colon: 31 nTPM
spleen: 31 nTPM
heart muscle: 30 nTPM

Single-cell type

enterocytes: 159 nCPM
extravillous trophoblasts: 138 nCPM
syncytiotrophoblasts: 120 nCPM
esophageal suprabasal cells: 86 nCPM
esophageal apical cells: 80 nCPM
migrating cytotrophoblasts: 72 nCPM

Immune cell

eosinophil: 27 nTPM
non-classical monocyte: 15 nTPM
naive B-cell: 15 nTPM
intermediate monocyte: 14 nTPM
T-reg: 13 nTPM
memory CD8 T-cell: 13 nTPM

Brain region

medulla oblongata: 15 nTPM
thalamus: 14 nTPM
pons: 13 nTPM
spinal cord: 13 nTPM
midbrain: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNIP2 as an antibody target. Whether an autoantibody or antibody against TNIP2 could matter depends on whether native TNIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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