Seroatlas · Human Serome Atlas

LRRC14

Leucine-rich repeat-containing protein 14

Also known as: KIAA0014, LRC14_HUMAN, LRRC14A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15048
Gene: LRRC14
Ensembl: ENSG00000160959
Chromosome: 8
Canonical length: 493 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q15048|LRRC14
     1  MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS
    61  FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE PGASTQPLCR KHALRVLDMT
   121  GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQGGAAEPGP APIPVEVRVD LRVNRASYAF
   181  LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI
   241  IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
   301  DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG SQLAPFQGLL
   361  QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL YGNPLSMAGL KELLRDSVAQ
   421  AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT
   481  DIYGRLAADY FSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 19 nTPM
prostate: 18 nTPM
cerebellum: 16 nTPM
thyroid gland: 16 nTPM
pancreas: 15 nTPM
endometrium: 15 nTPM

Single-cell type

early primary spermatocytes: 29 nCPM
differentiating spermatogonia: 28 nCPM
epididymal principal cells: 20 nCPM
respiratory ionocytes: 18 nCPM
plasma cells: 15 nCPM
enteric transient amplifying cells: 15 nCPM

Immune cell

NK-cell: 12 nTPM
gdT-cell: 8.4 nTPM
plasmacytoid DC: 8.4 nTPM
MAIT T-cell: 8 nTPM
total PBMC: 8 nTPM
naive B-cell: 7.9 nTPM

Brain region

cerebellum: 40 nTPM
hippocampal formation: 34 nTPM
cerebral cortex: 33 nTPM
white matter: 31 nTPM
amygdala: 31 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.16
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC14 as an antibody target. Whether an autoantibody or antibody against LRRC14 could matter depends on whether native LRRC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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