Seroatlas · Human Serome Atlas

ZNF268

Zinc finger protein 268

Also known as: HZF3, ZN268_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14587
Gene
ZNF268
Ensembl
ENSG00000090612
Chromosome
12
Canonical length
947 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; regulation of apoptotic process; and regulation of primary metabolic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

947 residues, UniProt reviewed canonical sequence.

>Q14587|ZNF268
     1  MATRVRTASI WVPPLQERNS SWDRIRKLQG QESILGQGTP GLQPLPGTPR QKQKSRRIEK
    61  VLEWLFISQE QPKITKSWGP LSFMDVFVDF TWEEWQLLDP AQKCLYRSVM LENYSNLVSL
   121  GYQHTKPDII FKLEQGEELC MVQAQVPNQT CPNTVWKIDD LMDWHQENKD KLGSTAKSFE
   181  CTTFGKLCLL STKYLSRQKP HKCGTHGKSL KYIDFTSDYA RNNPNGFQVH GKSFFHSKHE
   241  QTVIGIKYCE SIESGKTVNK KSQLMCQQMY MGEKPFGCSC CEKAFSSKSY LLVHQQTHAE
   301  EKPYGCNECG KDFSSKSYLI VHQRIHTGEK LHECSECRKT FSFHSQLVIH QRIHTGENPY
   361  ECCECGKVFS RKDQLVSHQK THSGQKPYVC NECGKAFGLK SQLIIHERIH TGEKPYECNE
   421  CQKAFNTKSN LMVHQRTHTG EKPYVCSDCG KAFTFKSQLI VHQGIHTGVK PYGCIQCGKG
   481  FSLKSQLIVH QRSHTGMKPY VCNECGKAFR SKSYLIIHTR THTGEKLHEC NNCGKAFSFK
   541  SQLIIHQRIH TGENPYECHE CGKAFSRKYQ LISHQRTHAG EKPYECTDCG KAFGLKSQLI
   601  IHQRTHTGEK PFECSECQKA FNTKSNLIVH QRTHTGEKPY SCNECGKAFT FKSQLIVHKG
   661  VHTGVKPYGC SQCAKTFSLK SQLIVHQRSH TGVKPYGCSE CGKAFRSKSY LIIHMRTHTG
   721  EKPHECRECG KSFSFNSQLI VHQRIHTGEN PYECSECGKA FNRKDQLISH QRTHAGEKPY
   781  GCSECGKAFS SKSYLIIHMR THSGEKPYEC NECGKAFIWK SLLIVHERTH AGVNPYKCSQ
   841  CEKSFSGKLR LLVHQRMHTR EKPYECSECG KAFIRNSQLI VHQRTHSGEK PYGCNECGKT
   901  FSQKSILSAH QRTHTGEKPC KCTECGKAFC WKSQLIMHQR THVDDKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF268 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 12 nTPM
  • liver: 12 nTPM
  • retina: 11 nTPM
  • thyroid gland: 10 nTPM
  • breast: 8.9 nTPM
  • placenta: 8.9 nTPM

Single-cell type

  • lacrimal acinar cells: 21 nCPM
  • differentiating spermatogonia: 21 nCPM
  • corticotrophs: 19 nCPM
  • epididymal clear cells: 18 nCPM
  • smooth muscle cells: 18 nCPM
  • cytotrophoblasts: 18 nCPM

Immune cell

  • naive CD4 T-cell: 14 nTPM
  • NK-cell: 11 nTPM
  • memory CD8 T-cell: 10 nTPM
  • naive CD8 T-cell: 10 nTPM
  • memory B-cell: 9.6 nTPM
  • memory CD4 T-cell: 9.3 nTPM

Brain region

  • cerebellum: 14 nTPM
  • choroid plexus: 14 nTPM
  • white matter: 12 nTPM
  • basal ganglia: 12 nTPM
  • cerebral cortex: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF268 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF268 as an antibody target. Whether an autoantibody or antibody against ZNF268 could matter depends on whether native ZNF268 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF268 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF268 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF268. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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