Seroatlas · Human Serome Atlas

CHUK

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Also known as: IkBKA, IKK-alpha, IKK1, IKKA, IKKA_HUMAN, NFKBIKA, TCF16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15111
Gene
CHUK
Ensembl
ENSG00000213341
Chromosome
10
Canonical length
745 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>O15111|CHUK
     1  MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH
    61  EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ
   121  ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS
   181  FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK
   241  CIFACEEMSG EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC
   301  FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI
   361  SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI
   421  IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL
   481  EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE
   541  IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV
   601  LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ
   661  SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP QDGETSAQMI EENLNCLGHL
   721  STIIHEANEE QGNSMMNLDW SWLTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHUK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 20 nTPM
  • bone marrow: 19 nTPM
  • liver: 16 nTPM
  • skeletal muscle: 13 nTPM
  • thymus: 13 nTPM
  • parathyroid gland: 13 nTPM

Single-cell type

  • neutrophils: 141 nCPM
  • neutrophil progenitors: 84 nCPM
  • monocyte progenitors: 49 nCPM
  • erythrocyte progenitors: 46 nCPM
  • early primary spermatocytes: 44 nCPM
  • corticotrophs: 42 nCPM

Immune cell

  • neutrophil: 2.8 nTPM
  • eosinophil: 2.1 nTPM
  • intermediate monocyte: 1.9 nTPM
  • NK-cell: 1.8 nTPM
  • memory B-cell: 1.6 nTPM
  • memory CD8 T-cell: 1.6 nTPM

Brain region

  • hypothalamus: 16 nTPM
  • white matter: 15 nTPM
  • choroid plexus: 14 nTPM
  • spinal cord: 13 nTPM
  • basal ganglia: 13 nTPM
  • medulla oblongata: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHUK.

Disease | AllUniProt

Conditions CHUK is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 290 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cocoon syndrome
  • Bartsocas-Papas syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2.78
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHUK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHUK as an antibody target. Whether an autoantibody or antibody against CHUK could matter depends on whether native CHUK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHUK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHUK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHUK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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