PPM1B

Protein identityUniProt · HPA

UniProt accession

O75688

Gene

PPM1B

Ensembl

ENSG00000138032

Chromosome

2

Canonical length

479 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>O75688|PPM1B
     1  MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD
    61  GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE NVKNGIRTGF LKIDEYMRNF
   121  SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI
   181  QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL
   241  ACDGIWDVMS NEELCEYVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK
   301  VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR
   361  NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL
   421  AKVEGEESPA EPAATATSSN SDAGNPVTMQ ESHTESESGL AELDSSNEDA GTKMSGEKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

123 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.66

gnomAD pLI

0.01

gnomAD missense Z

0.6

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• N-terminal protein myristoylation
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of defense response to virus
• negative regulation of interferon-beta production
• negative regulation of non-canonical NF-kappaB signal transduction
• peptidyl-threonine dephosphorylation
• positive regulation of canonical Wnt signaling pathway
• protein dephosphorylation
• regulation of canonical NF-kappaB signal transduction

Molecular functions

• magnesium ion binding
• manganese ion binding
• protein serine/threonine phosphatase activity

Cellular components

• cytosol
• membrane
• nucleolus
• nucleus

Protein domainsUniProt · Pfam · InterPro

• PPM-type phosphatase, divalent cation binding
• PPM-type phosphatase-like domain
• Protein serine/threonine phosphatase 2C, C-terminal
• Protein phosphatase 2C
• PPM-type phosphatase-like domain superfamily
• Phosphatase 2C, C-terminal domain superfamily
• Protein phosphatase 2C
• Protein serine/threonine phosphatase 2C, C-terminal domain

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Isopeptide bond
• Lipoprotein
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Myristate
• Phosphoprotein
• Protein phosphatase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PPM1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PAK6
• IKBKB
• ARRB1
• ARRB2
• ERBB3