Seroatlas · Human Serome Atlas

TICAM1

TIR domain-containing adapter molecule 1

Also known as: MGC35334, PRVTIRB, TCAM1_HUMAN, TICAM-1, TRIF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUC6
Gene
TICAM1
Ensembl
ENSG00000127666
Chromosome
19
Canonical length
712 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>Q8IUC6|TICAM1
     1  MACTGPSLPS AFDILGAAGQ DKLLYLKHKL KTPRPGCQGQ DLLHAMVLLK LGQETEARIS
    61  LEALKADAVA RLVARQWAGV DSTEDPEEPP DVSWAVARLY HLLAEEKLCP ASLRDVAYQE
   121  AVRTLSSRDD HRLGELQDEA RNRCGWDIAG DPGSIRTLQS NLGCLPPSSA LPSGTRSLPR
   181  PIDGVSDWSQ GCSLRSTGSP ASLASNLEIS QSPTMPFLSL HRSPHGPSKL CDDPQASLVP
   241  EPVPGGCQEP EEMSWPPSGE IASPPELPSS PPPGLPEVAP DATSTGLPDT PAAPETSTNY
   301  PVECTEGSAG PQSLPLPILE PVKNPCSVKD QTPLQLSVED TTSPNTKPCP PTPTTPETSP
   361  PPPPPPPSST PCSAHLTPSS LFPSSLESSS EQKFYNFVIL HARADEHIAL RVREKLEALG
   421  VPDGATFCED FQVPGRGELS CLQDAIDHSA FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ
   481  GSPDCVIPFL PLESSPAQLS SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW
   541  RKEQDTRALR EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG
   601  APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA FPQSLPFPQS
   661  PAFPTASPAP PQSPGLQPLI IHHAQMVQLG LNNHMWNQRG SQAPEDKTQE AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TICAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 44 nTPM
  • skin: 21 nTPM
  • liver: 19 nTPM
  • skeletal muscle: 19 nTPM
  • blood vessel: 17 nTPM
  • vagina: 17 nTPM

Single-cell type

  • esophageal apical cells: 405 nCPM
  • enterocytes: 334 nCPM
  • colonocytes: 262 nCPM
  • ocular epithelial cells: 184 nCPM
  • urothelial cells: 142 nCPM
  • endometrial glandular cells: 128 nCPM

Immune cell

  • non-classical monocyte: 7.1 nTPM
  • basophil: 6.8 nTPM
  • intermediate monocyte: 5.4 nTPM
  • total PBMC: 5 nTPM
  • classical monocyte: 4.1 nTPM
  • myeloid DC: 3.5 nTPM

Brain region

  • cerebral cortex: 14 nTPM
  • medulla oblongata: 13 nTPM
  • midbrain: 13 nTPM
  • thalamus: 13 nTPM
  • hypothalamus: 13 nTPM
  • pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TICAM1.

Disease | AllUniProt

Conditions TICAM1 is implicated in, by any mechanism.

  • Encephalopathy, acute, infection-induced, 6, herpes-specific (IIAE6) MIM:614850

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.72
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TICAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TICAM1 as an antibody target. Whether an autoantibody or antibody against TICAM1 could matter depends on whether native TICAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TICAM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TICAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TICAM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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