Seroatlas · Human Serome Atlas

IKBKE

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Also known as: IKK-i, IKKE, IKKE_HUMAN, KIAA0151

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14164
Gene
IKBKE
Ensembl
ENSG00000263528
Chromosome
1
Canonical length
716 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q14164|IKBKE
     1  MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTTSYLRPRE VQVREFEVLR
    61  KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV
   121  AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL
   181  HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE
   241  KPAGAIAGAQ RRENGPLEWS YTLPITCQLS LGLQSQLVPI LANILEVEQA KCWGFDQFFA
   301  ETSDILQRVV VHVFSLSQAV LHHIYIHAHN TIAIFQEAVH KQTSVAPRHQ EYLFEGHLCV
   361  LEPSVSAQHI AHTTASSPLT LFSTAIPKGL AFRDPALDVP KFVPKVDLQA DYNTAKGVLG
   421  AGYQALRLAR ALLDGQELMF RGLHWVMEVL QATCRRTLEV ARTSLLYLSS SLGTERFSSV
   481  AGTPEIQELK AAAELRSRLR TLAEVLSRCS QNITETQESL SSLNRELVKS RDQVHEDRSI
   541  QQIQCCLDKM NFIYKQFKKS RMRPGLGYNE EQIHKLDKVN FSHLAKRLLQ VFQEECVQKY
   601  QASLVTHGKR MRVVHETRNH LRLVGCSVAA CNTEAQGVQE SLSKLLEELS HQLLQDRAKG
   661  AQASPPPIAP YPSPTRKDLL LHMQELCEGM KLLASDLLDN NRIIERLNRV PAPPDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKBKE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 23 nTPM
  • tonsil: 19 nTPM
  • appendix: 16 nTPM
  • thymus: 15 nTPM
  • skin: 14 nTPM
  • esophagus: 14 nTPM

Single-cell type

  • esophageal suprabasal cells: 48 nCPM
  • foveolar cells: 28 nCPM
  • esophageal basal cells: 27 nCPM
  • paneth cells: 27 nCPM
  • monocytes: 26 nCPM
  • t-cells: 24 nCPM

Immune cell

  • T-reg: 53 nTPM
  • classical monocyte: 33 nTPM
  • memory CD4 T-cell: 33 nTPM
  • memory CD8 T-cell: 30 nTPM
  • total PBMC: 29 nTPM
  • naive CD8 T-cell: 27 nTPM

Brain region

  • white matter: 9.5 nTPM
  • basal ganglia: 9.3 nTPM
  • thalamus: 9.2 nTPM
  • medulla oblongata: 8.4 nTPM
  • pons: 8.3 nTPM
  • midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.01
gnomAD missense Z
2.08
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKBKE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKBKE as an antibody target. Whether an autoantibody or antibody against IKBKE could matter depends on whether native IKBKE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKBKE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKBKE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IKBKE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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