Seroatlas · Human Serome Atlas

MAP3K7

Mitogen-activated protein kinase kinase kinase 7

Also known as: M3K7_HUMAN, MEKK7, TAK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43318
Gene
MAP3K7
Ensembl
ENSG00000135341
Chromosome
6
Canonical length
606 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>O43318|MAP3K7
     1  MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV
    61  AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE
   121  PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC
   181  DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM
   241  WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
   301  PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ
   361  SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN
   421  ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP
   481  WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI
   541  ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ
   601  KRQGTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 21 nTPM
  • tongue: 18 nTPM
  • tonsil: 16 nTPM
  • heart muscle: 16 nTPM
  • skeletal muscle: 15 nTPM
  • placenta: 15 nTPM

Single-cell type

  • oligodendrocytes: 130 nCPM
  • neutrophil progenitors: 124 nCPM
  • pituicytes/fscs: 123 nCPM
  • innate lymphoid cells: 107 nCPM
  • lactotrophs: 107 nCPM
  • neutrophils: 105 nCPM

Immune cell

  • T-reg: 14 nTPM
  • eosinophil: 11 nTPM
  • NK-cell: 11 nTPM
  • intermediate monocyte: 10 nTPM
  • non-classical monocyte: 9.4 nTPM
  • myeloid DC: 8.4 nTPM

Brain region

  • white matter: 17 nTPM
  • spinal cord: 12 nTPM
  • medulla oblongata: 11 nTPM
  • pons: 11 nTPM
  • cerebellum: 11 nTPM
  • cerebral cortex: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP3K7.

Disease | AllUniProt

Conditions MAP3K7 is implicated in, by any mechanism.

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 402 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cardiospondylocarpofacial syndrome
  • Frontometaphyseal dysplasia 2
  • MAP3K7-related disorder

Disease | ImmuneIEDB

Conditions an epitope on MAP3K7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.79
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP3K7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP3K7 as an antibody target. Whether an autoantibody or antibody against MAP3K7 could matter depends on whether native MAP3K7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP3K7 is annotated at the cell surface, where native MAP3K7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAP3K7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP3K7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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