Seroatlas · Human Serome Atlas

MAP3K14

Mitogen-activated protein kinase kinase kinase 14

Also known as: FTDCR1B, HS, HSNIK, M3K14_HUMAN, NIK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99558
Gene: MAP3K14
Ensembl: ENSG00000006062
Chromosome: 17
Canonical length: 947 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

947 residues, UniProt reviewed canonical sequence.

>Q99558|MAP3K14
     1  MAVMEMACPG APGSAVGQQK ELPKAKEKTP PLGKKQSSVY KLEAVEKSPV FCGKWEILND
    61  VITKGTAKEG SEAGPAAISI IAQAECENSQ EFSPTFSERI FIAGSKQYSQ SESLDQIPNN
   121  VAHATEGKMA RVCWKGKRRS KARKKRKKKS SKSLAHAGVA LAKPLPRTPE QESCTIPVQE
   181  DESPLGAPYV RNTPQFTKPL KEPGLGQLCF KQLGEGLRPA LPRSELHKLI SPLQCLNHVW
   241  KLHHPQDGGP LPLPTHPFPY SRLPHPFPFH PLQPWKPHPL ESFLGKLACV DSQKPLPDPH
   301  LSKLACVDSP KPLPGPHLEP SCLSRGAHEK FSVEEYLVHA LQGSVSSGQA HSLTSLAKTW
   361  AARGSRSREP SPKTEDNEGV LLTEKLKPVD YEYREEVHWA THQLRLGRGS FGEVHRMEDK
   421  QTGFQCAVKK VRLEVFRAEE LMACAGLTSP RIVPLYGAVR EGPWVNIFME LLEGGSLGQL
   481  VKEQGCLPED RALYYLGQAL EGLEYLHSRR ILHGDVKADN VLLSSDGSHA ALCDFGHAVC
   541  LQPDGLGKSL LTGDYIPGTE THMAPEVVLG RSCDAKVDVW SSCCMMLHML NGCHPWTQFF
   601  RGPLCLKIAS EPPPVREIPP SCAPLTAQAI QEGLRKEPIH RVSAAELGGK VNRALQQVGG
   661  LKSPWRGEYK EPRHPPPNQA NYHQTLHAQP RELSPRAPGP RPAEETTGRA PKLQPPLPPE
   721  PPEPNKSPPL TLSKEESGMW EPLPLSSLEP APARNPSSPE RKATVPEQEL QQLEIELFLN
   781  SLSQPFSLEE QEQILSCLSI DSLSLSDDSE KNPSKASQSS RDTLSSGVHS WSSQAEARSS
   841  SWNMVLARGR PTDTPSYFNG VKVQIQSLNG EHLHIREFHR VKVGDIATGI SSQIPAAAFS
   901  LVTKDGQPVR YDMEVPDSGI DLQCTLAPDG SFAWSWRVKH GQLENRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 25 nTPM
lymph node: 17 nTPM
tonsil: 15 nTPM
colon: 14 nTPM
thymus: 13 nTPM
appendix: 12 nTPM

Single-cell type

epicardial cells: 130 nCPM
cdc: 127 nCPM
renal connecting tubule cells: 123 nCPM
myosatellite cells: 113 nCPM
epididymal basal cells: 110 nCPM
microglia: 108 nCPM

Immune cell

naive B-cell: 4.4 nTPM
memory B-cell: 4.2 nTPM
T-reg: 3 nTPM
classical monocyte: 2 nTPM
NK-cell: 2 nTPM
intermediate monocyte: 1.8 nTPM

Brain region

basal ganglia: 13 nTPM
thalamus: 13 nTPM
midbrain: 13 nTPM
medulla oblongata: 11 nTPM
hippocampal formation: 9.8 nTPM
pons: 9.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP3K14.

Disease | AllUniProt

Conditions MAP3K14 is implicated in, by any mechanism.

Immunodeficiency 112 (IMD112) MIM:620449

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 557 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

NIK deficiency
Immunodeficiency 112

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Mitogen-activated protein kinase kinase kinase
Protein kinase domain
Mitogen-activated protein (MAP) kinase kinase kinase 14
M3K14, catalytic domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP3K14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP3K14 as an antibody target. Whether an autoantibody or antibody against MAP3K14 could matter depends on whether native MAP3K14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP3K14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP3K14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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