FAF1

Protein identityUniProt · HPA

UniProt accession

Q9UNN5

Gene

FAF1

Ensembl

ENSG00000185104

Chromosome

1

Canonical length

650 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Acrosome,Equatorial segment,Perinuclear theca

OverviewNCBI Gene

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

650 residues, UniProt reviewed canonical sequence.

>Q9UNN5|FAF1
     1  MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSEYGGET
    61  IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDTC
   121  TVGEIKQILE NELQIPVSKM LLKGWKTGDV EDSTVLKSLH LPKNNSLYVL TPDLPPPSSS
   181  SHAGALQESL NQNFMLIITH REVQREYNLN FSGSSTIQEV KRNVYDLTSI PVRHQLWEGW
   241  PTSATDDSMC LAESGLSYPC HRLTVGRRSS PAQTREQSEE QITDVHMVSD SDGDDFEDAT
   301  EFGVDDGEVF GMASSALRKS PMMPENAENE GDALLQFTAE FSSRYGDCHP VFFIGSLEAA
   361  FQEAFYVKAR DRKLLAIYLH HDESVLTNVF CSQMLCAESI VSYLSQNFIT WAWDLTKDSN
   421  RARFLTMCNR HFGSVVAQTI RTQKTDQFPL FLIIMGKRSS NEVLNVIQGN TTVDELMMRL
   481  MAAMEIFTAQ QQEDIKDEDE REARENVKRE QDEAYRLSLE ADRAKREAHE REMAEQFRLE
   541  QIRKEQEEER EAIRLSLEQA LPPEPKEENA EPVSKLRIRT PSGEFLERRF LASNKLQIVF
   601  DFVASKGFPW DEYKLLSTFP RRDVTQLDPN KSLLEVKLFP QETLFLEAKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

2.13

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• ERAD pathway
• Fas signaling pathway
• negative regulation of canonical NF-kappaB signal transduction
• positive regulation of apoptotic process
• positive regulation of DNA replication
• positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
• positive regulation of protein catabolic process
• proteasome-mediated ubiquitin-dependent protein catabolic process
• regulation of cell adhesion
• regulation of protein catabolic process

Molecular functions

• heat shock protein binding
• NF-kappaB binding
• protein domain specific binding
• protein kinase binding
• protein kinase regulator activity
• ubiquitin binding
• ubiquitin protein ligase binding

Cellular components

• acrosomal vesicle
• CD95 death-inducing signaling complex
• cytosol
• endoplasmic reticulum
• nuclear envelope
• nucleoplasm
• nucleus
• ooplasm
• perinuclear region of cytoplasm
• perinuclear theca
• VCP-NPL4-UFD1 AAA ATPase complex

Protein domainsUniProt · Pfam · InterPro

• UBX domain
• UAS
• Ubiquitin-like domain superfamily
• Thioredoxin-like superfamily
• Fas-associated factor 1/2-like, UAS domain
• UBX domain-containing protein
• UBX domain
• UBA-like domain
• Fas-associated factor 1
• FAS-associated factor 1-like, UBX domain
• FAF1, UBA-like domain

KeywordsUniProt

• Apoptosis
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of FAF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDT1
• IKBKB
• HSPA8
• NPLOC4
• UFD1
• VCP
• YTHDF3