Seroatlas · Human Serome Atlas

GORASP2

Golgi reassembly-stacking protein 2

Also known as: GOLPH6, GORS2_HUMAN, GRASP55, GRS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8Y8
Gene
GORASP2
Ensembl
ENSG00000115806
Chromosome
2
Canonical length
452 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q9H8Y8|GORASP2
     1  MGSSQSVEIP GGGTEGYHVL RVQENSPGHR AGLEPFFDFI VSINGSRLNK DNDTLKDLLK
    61  ANVEKPVKML IYSSKTLELR ETSVTPSNLW GGQGLLGVSI RFCSFDGANE NVWHVLEVES
   121  NSPAALAGLR PHSDYIIGAD TVMNESEDLF SLIETHEAKP LKLYVYNTDT DNCREVIITP
   181  NSAWGGEGSL GCGIGYGYLH RIPTRPFEEG KKISLPGQMA GTPITPLKDG FTEVQLSSVN
   241  PPSLSPPGTT GIEQSLTGLS ISSTPPAVSS VLSTGVPTVP LLPPQVNQSL TSVPPMNPAT
   301  TLPGLMPLPA GLPNLPNLNL NLPAPHIMPG VGLPELVNPG LPPLPSMPPR NLPGIAPLPL
   361  PSEFLPSFPL VPESSSAASS GELLSSLPPT SNAPSDPATT TAKADAASSL TVDVTPPTAK
   421  APTTVEDRVG DSTPVSEKPV SAAVDANASE SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GORASP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 67 nTPM
  • salivary gland: 64 nTPM
  • cervix: 59 nTPM
  • epididymis: 57 nTPM
  • pituitary gland: 56 nTPM
  • blood vessel: 55 nTPM

Single-cell type

  • late spermatids: 640 nCPM
  • syncytiotrophoblasts: 375 nCPM
  • early spermatids: 249 nCPM
  • extravillous trophoblasts: 235 nCPM
  • cytotrophoblasts: 178 nCPM
  • plasma cells: 176 nCPM

Immune cell

  • MAIT T-cell: 82 nTPM
  • NK-cell: 65 nTPM
  • plasmacytoid DC: 64 nTPM
  • memory CD8 T-cell: 63 nTPM
  • total PBMC: 63 nTPM
  • memory CD4 T-cell: 59 nTPM

Brain region

  • white matter: 37 nTPM
  • hypothalamus: 35 nTPM
  • cerebellum: 35 nTPM
  • pons: 33 nTPM
  • midbrain: 33 nTPM
  • medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.88
gnomAD missense Z
1.59
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GORASP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GORASP2 as an antibody target. Whether an autoantibody or antibody against GORASP2 could matter depends on whether native GORASP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GORASP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GORASP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GORASP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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