Seroatlas · Human Serome Atlas

TMED10

Transmembrane emp24 domain-containing protein 10

Also known as: p23, P24(DELTA), p24d1, p24delta1, TMEDA_HUMAN, TMP21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49755
Gene
TMED10
Ensembl
ENSG00000170348
Chromosome
14
Canonical length
219 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>P49755|TMED10
     1  MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK DLLVTGAYEI
    61  SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ
   121  LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE
   181  STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 137 nTPM
  • cervix: 130 nTPM
  • epididymis: 126 nTPM
  • pancreas: 126 nTPM
  • salivary gland: 124 nTPM
  • liver: 119 nTPM

Single-cell type

  • esophageal apical cells: 950 nCPM
  • extravillous trophoblasts: 882 nCPM
  • epididymal principal cells: 691 nCPM
  • plasma cells: 526 nCPM
  • lacrimal acinar cells: 499 nCPM
  • esophageal suprabasal cells: 472 nCPM

Immune cell

  • basophil: 109 nTPM
  • NK-cell: 103 nTPM
  • MAIT T-cell: 95 nTPM
  • total PBMC: 92 nTPM
  • plasmacytoid DC: 72 nTPM
  • myeloid DC: 63 nTPM

Brain region

  • white matter: 96 nTPM
  • hypothalamus: 94 nTPM
  • medulla oblongata: 93 nTPM
  • choroid plexus: 82 nTPM
  • spinal cord: 74 nTPM
  • pons: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.86
gnomAD missense Z
2.14
DepMap mean gene effect
-0.64
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMED10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED10 as an antibody target. Whether an autoantibody or antibody against TMED10 could matter depends on whether native TMED10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED10 is annotated at the cell surface, where native TMED10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMED10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMED10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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