TMED2
Transmembrane emp24 domain-containing protein 2
Also known as: P24A, p24b1, p24beta1, RNP24, TMED2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15363
- Gene
- TMED2
- Ensembl
- ENSG00000086598
- Chromosome
- 12
- Canonical length
- 201 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Vesicles
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable frizzled binding activity and smoothened binding activity. Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
201 residues, UniProt reviewed canonical sequence.
>Q15363|TMED2
1 MVTLAELLVL LAALLATVSG YFVSIDAHAE ECFFERVTSG TKMGLIFEVA EGGFLDIDVE
61 ITGPDNKGIY KGDRESSGKY TFAAHMDGTY KFCFSNRMST MTPKIVMFTI DIGEAPKGQD
121 METEAHQNKL EEMINELAVA MTAVKHEQEY MEVRERIHRA INDNTNSRVV LWSFFEALVL
181 VAMTLGQIYY LKRFFEVRRV VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMED2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 253 nTPM
Expression across tissuesHPA
Tissue
- liver: 253 nTPM
- pancreas: 216 nTPM
- salivary gland: 214 nTPM
- epididymis: 192 nTPM
- thyroid gland: 185 nTPM
- cervix: 146 nTPM
Single-cell type
- extravillous trophoblasts: 918 nCPM
- gastric chief cells: 671 nCPM
- esophageal apical cells: 669 nCPM
- epididymal principal cells: 654 nCPM
- hepatocytes: 621 nCPM
- parietal cells: 573 nCPM
Immune cell
- basophil: 250 nTPM
- plasmacytoid DC: 243 nTPM
- MAIT T-cell: 199 nTPM
- myeloid DC: 159 nTPM
- gdT-cell: 157 nTPM
- NK-cell: 149 nTPM
Brain region
- choroid plexus: 92 nTPM
- white matter: 76 nTPM
- medulla oblongata: 65 nTPM
- midbrain: 65 nTPM
- spinal cord: 63 nTPM
- hypothalamus: 62 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.41
- gnomAD pLI
- 0.89
- gnomAD missense Z
- 1.91
- DepMap mean gene effect
- -0.58
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- allantois development
- branching involved in labyrinthine layer morphogenesis
- chorion development
- COPI coating of Golgi vesicle
- COPII vesicle coating
- dorsal/ventral neural tube patterning
- endoplasmic reticulum membrane organization
- endoplasmic reticulum to Golgi vesicle-mediated transport
- Golgi organization
- heart looping
- inflammatory response
- intracellular protein transport
- labyrinthine layer blood vessel development
- maintenance of protein localization in organelle
- maternal placenta development
- multicellular organism growth
- negative regulation of GTPase activity
- negative regulation of protein localization to plasma membrane
- negative regulation of smoothened signaling pathway
- neural tube closure
- PERK-mediated unfolded protein response
- positive regulation of gene expression
- post-anal tail morphogenesis
- protein localization to plasma membrane
- protein secretion
- regulation of SREBP signaling pathway
- somite rostral/caudal axis specification
- vesicle cargo loading
Molecular functions
Cellular components
- COPI-coated vesicle
- COPI-coated vesicle membrane
- COPII-coated ER to Golgi transport vesicle
- endoplasmic reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
- ER to Golgi transport vesicle membrane
- Golgi apparatus
- Golgi cisterna membrane
- Golgi membrane
- membrane
- transport vesicle
- zymogen granule membrane
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMED2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMED2 as an antibody target. Whether an autoantibody or antibody against TMED2 could matter depends on whether native TMED2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMED2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMED2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...