Seroatlas · Human Serome Atlas

TXLNA

Alpha-taxilin

Also known as: DKFZp451J0118, TXLNA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40222
Gene: TXLNA
Ensembl: ENSG00000084652
Chromosome: 1
Canonical length: 546 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>P40222|TXLNA
     1  MKNQDKKNGA AKQSNPKSSP GQPEAGPEGA QERPSQAAPA VEAEGPGSSQ APRKPEGAQA
    61  RTAQSGALRD VSEELSRQLE DILSTYCVDN NQGGPGEDGA QGEPAEPEDA EKSRTYVARN
   121  GEPEPTPVVN GEKEPSKGDP NTEEIRQSDE VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN
   181  TLSTPEEKLA ALCKKYAELL EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK
   241  LESLCRELQR HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ
   301  ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE AEERHQREKD
   361  FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT LSKSSEVFTT FKQEMEKMTK
   421  KIKKLEKETT MYRSRWESSN KALLEMAEEK TVRDKELEGL QVKIQRLEKL CRALQTERND
   481  LNKRVQDLSA GGQGSLTDSG PERRPEGPGA QAPSSPRVTE APCYPGAPST EASGQTGPQE
   541  PTSARA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXLNA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
adrenal gland: 34 nTPM
endometrium: 33 nTPM
colon: 31 nTPM
blood vessel: 31 nTPM
parathyroid gland: 31 nTPM

Single-cell type

endometrial stromal cells: 54 nCPM
pdcs: 53 nCPM
salivary myoepithelial cells: 52 nCPM
plasma cells: 50 nCPM
pancreatic islet cells: 47 nCPM
thymic myoid cells: 46 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
NK-cell: 14 nTPM
non-classical monocyte: 13 nTPM
gdT-cell: 13 nTPM
MAIT T-cell: 11 nTPM
basophil: 11 nTPM

Brain region

choroid plexus: 43 nTPM
medulla oblongata: 39 nTPM
thalamus: 36 nTPM
midbrain: 34 nTPM
hypothalamus: 33 nTPM
pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.58
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

syntaxin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXLNA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXLNA as an antibody target. Whether an autoantibody or antibody against TXLNA could matter depends on whether native TXLNA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXLNA is annotated as secreted, so native TXLNA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TXLNA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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