Seroatlas · Human Serome Atlas

BEND5

BEN domain-containing protein 5

Also known as: BEND5_HUMAN, C1orf165, FLJ11588

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L4P6
Gene: BEND5
Ensembl: ENSG00000162373
Chromosome: 1
Canonical length: 421 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q7L4P6|BEND5
     1  MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAG PESPPRAPRD
    61  WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLNHV EEDGEVKDYG EEDLQLRHIK
   121  RPEGRKPSEV AHKSIEAVVA RLEKQNGLSL GHSTCPEEVF VEASPGTEDM DSLEDAVVPR
   181  ALYEELLRNY QQQQEEMRHL QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD
   241  VLLLRLGSGP AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH
   301  LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK KKDAVPKPPL
   361  SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK IMDINKSCKN EERREAKYNL
   421  Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEND5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.6 nTPM
thymus: 4.5 nTPM
ovary: 4.4 nTPM
amygdala: 3.7 nTPM
pituitary gland: 3.5 nTPM
retina: 3.5 nTPM

Single-cell type

medullary thymic epithelial cells: 46 nCPM
respiratory secretory cells: 44 nCPM
breast myoepithelial cells: 31 nCPM
respiratory basal cells: 28 nCPM
epididymal efferent duct absorptive cells: 25 nCPM
conjunctival goblet cells: 20 nCPM

Immune cell

naive B-cell: 8.1 nTPM
memory B-cell: 6.5 nTPM
myeloid DC: 1.7 nTPM
plasmacytoid DC: 1.7 nTPM
naive CD4 T-cell: 1.6 nTPM
NK-cell: 1.2 nTPM

Brain region

cerebral cortex: 9.9 nTPM
pons: 7.8 nTPM
white matter: 5.4 nTPM
hippocampal formation: 5.1 nTPM
basal ganglia: 5 nTPM
medulla oblongata: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.05
gnomAD missense Z: 1.7
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

BEN domain
BEN domain
BEN domain-containing protein 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEND5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEND5 as an antibody target. Whether an autoantibody or antibody against BEND5 could matter depends on whether native BEND5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEND5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEND5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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