JAM2

Protein identityUniProt · HPA

UniProt accession

P57087

Gene

JAM2

Ensembl

ENSG00000154721

Chromosome

21

Canonical length

298 aa

Protein class

CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P57087|JAM2
     1  MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC KTPKKTVSSR
    61  LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN
   121  LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR
   181  LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI
   241  IAAVVVVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

60 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JAM2.

Disease | AllUniProt

Conditions JAM2 is implicated in, by any mechanism.

• Basal ganglia calcification, idiopathic, 8, autosomal recessive (IBGC8) MIM:618824

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Basal ganglia calcification, idiopathic, 8, autosomal recessive
• JAM2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0.01

gnomAD missense Z

1.08

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell adhesion
• cellular extravasation
• hematopoietic stem cell migration to bone marrow
• leukocyte cell-cell adhesion
• leukocyte tethering or rolling
• lymphocyte aggregation
• maintenance of blood-brain barrier
• negative regulation of myelination
• positive regulation of lymphocyte migration
• spermatid development

Molecular functions

• integrin binding

Cellular components

• bicellular tight junction
• cell surface
• cell-cell contact zone
• plasma membrane
• protein complex involved in cell adhesion
• somatodendritic compartment
• tight junction

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoglobulin V-set domain
• Immunoglobulin domain
• Junctional adhesion molecule B

KeywordsUniProt

• Cell junction
• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Membrane
• Signal
• Tight junction
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of JAM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GORASP2