Seroatlas · Human Serome Atlas

TRAF4

TNF receptor-associated factor 4

Also known as: CART1, MLN62, RNF83, TRAF4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUZ4
Gene
TRAF4
Ensembl
ENSG00000076604
Chromosome
17
Canonical length
470 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q9BUZ4|TRAF4
     1  MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP
    61  LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK
   121  LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL
   181  AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVA CPNQCGVGTV AREDLPGHLK
   241  DSCNTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE
   301  ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG
   361  THLSLYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP
   421  GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA AVELPRKILS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • liver: 58 nTPM
  • salivary gland: 46 nTPM
  • duodenum: 44 nTPM
  • small intestine: 37 nTPM
  • kidney: 36 nTPM
  • stomach: 35 nTPM

Single-cell type

  • epididymal basal cells: 226 nCPM
  • urothelial cells: 226 nCPM
  • pdcs: 177 nCPM
  • extravillous trophoblasts: 170 nCPM
  • breast secretory cells: 161 nCPM
  • endometrial glandular cells: 157 nCPM

Immune cell

  • plasmacytoid DC: 43 nTPM
  • memory B-cell: 8.1 nTPM
  • naive B-cell: 6.9 nTPM
  • basophil: 4.7 nTPM
  • myeloid DC: 2.2 nTPM
  • MAIT T-cell: 1.9 nTPM

Brain region

  • white matter: 33 nTPM
  • medulla oblongata: 25 nTPM
  • cerebral cortex: 23 nTPM
  • midbrain: 23 nTPM
  • basal ganglia: 22 nTPM
  • choroid plexus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.94
gnomAD missense Z
2.42
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF4 as an antibody target. Whether an autoantibody or antibody against TRAF4 could matter depends on whether native TRAF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF4 is annotated at the cell surface, where native TRAF4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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