Seroatlas · Human Serome Atlas

LONRF1

LON peptidase N-terminal domain and RING finger protein 1

Also known as: FLJ23749, LONF1_HUMAN, RNF191

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RB8
Gene: LONRF1
Ensembl: ENSG00000154359
Chromosome: 8
Canonical length: 773 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>Q17RB8|LONRF1
     1  MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL
    61  GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL
   121  LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE LRARCRLCRD RLPPATASAT DAEGTAPRPP
   181  PLAAAIAASD FRTSVVLNHL AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA
   241  EPSDLIVKIY RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ
   301  LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR PFDFHSVMEE
   361  SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE MPAREDCLKR VSSEPVLSVQ
   421  EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ GETPNEVCMF SLAYGDIPEE LIDVSDFECS
   481  LCMRLFFEPV TTPCGHSFCK NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV
   541  KYLPDELSER KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ
   601  TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL KRGMKDGYCT
   661  ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD RFRSQILQHF GSMPEREENL
   721  QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM KSLKERLTKI QHILTYFSRD QSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LONRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skin: 26 nTPM
skeletal muscle: 15 nTPM
adipose tissue: 15 nTPM
testis: 15 nTPM
esophagus: 12 nTPM
blood vessel: 12 nTPM

Single-cell type

bergmann glia: 97 nCPM
podocytes: 87 nCPM
brain inhibitory neurons: 61 nCPM
brain excitatory neurons: 60 nCPM
distal convoluted tubule cells: 54 nCPM
choroid plexus epithelial cells: 51 nCPM

Immune cell

eosinophil: 0.6 nTPM
intermediate monocyte: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
neutrophil: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 10 nTPM
hippocampal formation: 9.5 nTPM
white matter: 9.4 nTPM
cerebral cortex: 9.3 nTPM
basal ganglia: 9 nTPM
thalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.61
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LONRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LONRF1 as an antibody target. Whether an autoantibody or antibody against LONRF1 could matter depends on whether native LONRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LONRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LONRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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