Seroatlas · Human Serome Atlas

LAMP1

Lysosome-associated membrane glycoprotein 1

Also known as: CD107a, LAMP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11279
Gene: LAMP1
Ensembl: ENSG00000185896
Chromosome: 13
Canonical length: 417 aa
Protein class: CD markers, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>P11279|LAMP1
     1  MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP
    61  KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY
   121  NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS
   181  NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL
   241  NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF
   301  LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ
   361  AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 217 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 217 nTPM
liver: 174 nTPM
skin: 173 nTPM
pancreas: 164 nTPM
spinal cord: 152 nTPM
kidney: 143 nTPM

Single-cell type

late spermatids: 1,055 nCPM
esophageal apical cells: 666 nCPM
esophageal suprabasal cells: 417 nCPM
syncytiotrophoblasts: 399 nCPM
hepatocytes: 351 nCPM
kupffer cells: 343 nCPM

Immune cell

eosinophil: 9.5 nTPM
neutrophil: 6.9 nTPM
plasmacytoid DC: 5.4 nTPM
classical monocyte: 4.9 nTPM
memory CD8 T-cell: 4.4 nTPM
non-classical monocyte: 4.4 nTPM

Brain region

white matter: 228 nTPM
medulla oblongata: 207 nTPM
basal ganglia: 192 nTPM
thalamus: 191 nTPM
cerebellum: 188 nTPM
midbrain: 171 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.87
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMP1 as an antibody target. Whether an autoantibody or antibody against LAMP1 could matter depends on whether native LAMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMP1 is annotated at the cell surface, where native LAMP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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