Seroatlas · Human Serome Atlas

BLZF1

Golgin-45

Also known as: GO45_HUMAN, JEM-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2G9
Gene
BLZF1
Ensembl
ENSG00000117475
Chromosome
1
Canonical length
400 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Acts upstream of or within Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus and nucleoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9H2G9|BLZF1
     1  MTTKNLETKV TVTSSPIRGA GDGMETEEPP KSVEVTSGVQ SRKHHSLQSP WKKAVPSESP
    61  GVLQLGKMLT EKAMEVKAVR ILVPKAAITH DIPNKNTKVK SLGHHKGEFL GQSEGVIEPN
   121  KELSEVKNVL EKLKNSERRL LQDKEGLSNQ LRVQTEVNRE LKKLLVASVG DDLQYHFERL
   181  AREKNQLILE NEALGRNTAQ LSEQLERMSI QCDVWRSKFL ASRVMADELT NSRAALQRQN
   241  RDAHGAIQDL LSEREQFRQE MIATQKLLEE LLVSLQWGRE QTYSPSVQPH STAELALTNH
   301  KLAKAVNSHL LGNVGINNQK KIPSTVEFCS TPAEKMAETV LRILDPVTCK ESSPDNPFFE
   361  SSPTTLLATK KNIGRFHPYT RYENITFNCC NHCRGELIAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLZF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • esophagus: 30 nTPM
  • bone marrow: 24 nTPM
  • retina: 21 nTPM
  • breast: 18 nTPM
  • thyroid gland: 18 nTPM

Single-cell type

  • esophageal apical cells: 314 nCPM
  • late primary spermatocytes: 181 nCPM
  • epididymal basal cells: 180 nCPM
  • early spermatids: 137 nCPM
  • ocular epithelial cells: 116 nCPM
  • urothelial cells: 113 nCPM

Immune cell

  • basophil: 86 nTPM
  • eosinophil: 52 nTPM
  • neutrophil: 25 nTPM
  • T-reg: 24 nTPM
  • NK-cell: 20 nTPM
  • intermediate monocyte: 16 nTPM

Brain region

  • white matter: 34 nTPM
  • cerebellum: 30 nTPM
  • basal ganglia: 27 nTPM
  • medulla oblongata: 27 nTPM
  • spinal cord: 27 nTPM
  • cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • DASH complex subunit Hsk3-like
  • Golgin-45
  • DASH complex subunit Hsk3 like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BLZF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLZF1 as an antibody target. Whether an autoantibody or antibody against BLZF1 could matter depends on whether native BLZF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLZF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BLZF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BLZF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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