PDE9A

Protein identityUniProt · HPA

UniProt accession

O76083

Gene

PDE9A

Ensembl

ENSG00000160191

Chromosome

21

Canonical length

593 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>O76083|PDE9A
     1  MGSGSSSYRP KAIYLDIDGR IQKVIFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM
    61  VSIDPTMPAN SERTPYKVRP VAIKQLSAGV EDKRTTSRGQ SAERPLRDRR VVGLEQPRRE
   121  GAFESGQVEP RPREPQGCYQ EGQRIPPERE ELIQSVLAQV AEQFSRAFKI NELKAEVANH
   181  LAVLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARSSRTN CPCKYSFLDN HKKLTPRRDV
   241  PTYPKYLLSP ETIEALRKPT FDVWLWEPNE MLSCLEHMYH DLGLVRDFSI NPVTLRRWLF
   301  CVHDNYRNNP FHNFRHCFCV AQMMYSMVWL CSLQEKFSQT DILILMTAAI CHDLDHPGYN
   361  NTYQINARTE LAVRYNDISP LENHHCAVAF QILAEPECNI FSNIPPDGFK QIRQGMITLI
   421  LATDMARHAE IMDSFKEKME NFDYSNEEHM TLLKMILIKC CDISNEVRPM EVAEPWVDCL
   481  LEEYFMQSDR EKSEGLPVAP FMDRDKVTKA TAQIGFIKFV LIPMFETVTK LFPMVEEIML
   541  QPLWESRDRY EELKRIDDAM KELQKKTDSL TSGATEKSRE RSRDVKNSEG DCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

70 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.49

gnomAD pLI

0

gnomAD missense Z

1.09

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cGMP catabolic process
• cGMP metabolic process
• negative regulation of cAMP/PKA signal transduction
• negative regulation of neural precursor cell proliferation
• positive regulation of cardiac muscle hypertrophy
• positive regulation of long-term synaptic potentiation
• signal transduction

Molecular functions

• 3',5'-cyclic-AMP phosphodiesterase activity
• 3',5'-cyclic-GMP phosphodiesterase activity
• 3',5'-cyclic-nucleotide phosphodiesterase activity
• identical protein binding
• metal ion binding

Cellular components

• cytosol
• endoplasmic reticulum
• Golgi apparatus
• nucleoplasm
• perikaryon
• perinuclear region of cytoplasm
• plasma membrane
• ruffle membrane
• sarcolemma

Protein domainsUniProt · Pfam · InterPro

• 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
• HD/PDEase domain
• 3'5'-cyclic nucleotide phosphodiesterase
• 3'5'-cyclic nucleotide phosphodiesterase, conserved site
• 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
• 3'5'-cyclic nucleotide phosphodiesterase

KeywordsUniProt

• Cell membrane
• Cell projection
• cGMP
• Cytoplasm
• Endoplasmic reticulum
• Golgi apparatus
• Hydrolase
• Magnesium
• Membrane
• Metal-binding
• Phosphoprotein
• Zinc

InteractionsUniProt · HPA

Protein binding partners of PDE9A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GORASP2