Seroatlas · Human Serome Atlas

C1orf94

Uncharacterized protein C1orf94

Also known as: CA094_HUMAN, MGC15882

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1W5
Gene
C1orf94
Ensembl
ENSG00000142698
Chromosome
1
Canonical length
598 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for C1orf94 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

598 residues, UniProt reviewed canonical sequence.

>Q6P1W5|C1orf94
     1  MRGGGGCVLA LGGQRGFQKE RRRMASGNGL PSSSALVAKG PCALGPFPRY IWIHQDTPQD
    61  SLDKTCHEIW KRVQGLPEAS QPWTSMEQLS VPVVGTLRGN ELSFQEEALE LSSGKDEISL
   121  LVEQEFLSLT KEHSILVEES SGELEVPGSS PEGTRELAPC ILAPPLVAGS NERPRASIIV
   181  GDKLLKQKVA MPVISSRQDC DSATSTVTDI LCAAEVKSSK GTEDRGRILG DSNLQVSKLL
   241  SQFPLKSTET SKVPDNKNVL DKTRVTKDFL QDNLFSGPGP KEPTGLSPFL LLPPRPPPAR
   301  PDKLPELPAQ KRQLPVFAKI CSKPKADPAV ERHHLMEWSP GTKEPKKGQG SLFLSQWPQS
   361  QKDACGEEGC CDAVGTASLT LPPKKPTCPA EKNLLYEFLG ATKNPSGQPR LRNKVEVDGP
   421  ELKFNAPVTV ADKNNPKYTG NVFTPHFPTA MTSATLNQPL WLNLNYPPPP VFTNHSTFLQ
   481  YQGLYPQQAA RMPYQQALHP QLGCYSQQVM PYNPQQMGQQ IFRSSYTPLL SYIPFVQPNY
   541  PYPQRTPPKM SANPRDPPLM AGDGPQYLFP QGYGFGSTSG GPLMHSPYFS SSGNGINF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf94 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • cerebral cortex: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • hypothalamus: 0.6 nTPM
  • spinal cord: 0.6 nTPM
  • hippocampal formation: 0.5 nTPM

Single-cell type

  • late primary spermatocytes: 108 nCPM
  • early spermatids: 85 nCPM
  • late spermatids: 45 nCPM
  • early primary spermatocytes: 5.4 nCPM
  • sertoli cells: 2.5 nCPM
  • cone photoreceptor cells: 2.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.7 nTPM
  • spinal cord: 1.6 nTPM
  • hypothalamus: 1.5 nTPM
  • cerebral cortex: 1 nTPM
  • medulla oblongata: 1 nTPM
  • amygdala: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.01
gnomAD missense Z
0.25
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4688
  • Domain of unknown function (DUF4688)

InteractionsUniProt · HPA

Protein binding partners of C1orf94 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf94 as an antibody target. Whether an autoantibody or antibody against C1orf94 could matter depends on whether native C1orf94 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf94 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf94 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf94. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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