Seroatlas · Human Serome Atlas

SLC30A5

Proton-coupled zinc antiporter SLC30A5

Also known as: FLJ12496, FLJ12756, MGC5499, ZnT-5, ZNT5, ZNT5_HUMAN, ZNTL1, ZTL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAD4
Gene
SLC30A5
Ensembl
ENSG00000145740
Chromosome
5
Canonical length
765 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q8TAD4|SLC30A5
     1  MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES YDLLKAVHIV
    61  QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV AGCIISLLWF FGLTLCGPLR
   121  TLLLFEHSDI VVISLLSVLF TSSGGGPAKT RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE
   181  GHHDSALTHM LYTAIAFLGV ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL
   241  SHLVSVLLLC PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK
   301  CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV SAIFFILSAN
   361  ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP RFIKESLKQI LEESDSRQIF
   421  YFLCLNLLFT FVELFYGVLT NSLGLISDGF HMLFDCSALV MGLFAALMSR WKATRIFSYG
   481  YGRIEILSGF INGLFLIVIA FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF
   541  SHAHSHAHGA SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT
   601  LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL RLPPEYEKEL
   661  HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD VLEQRIVQQV TGILKDAGVN
   721  NLTIQVEKEA YFQHMSGLST GFHDVLAMTK QMESMKYCKD GTYIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
16
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 36 nTPM
  • thyroid gland: 35 nTPM
  • parathyroid gland: 34 nTPM
  • pancreas: 30 nTPM
  • salivary gland: 29 nTPM
  • breast: 28 nTPM

Single-cell type

  • megakaryocyte progenitors: 188 nCPM
  • platelets: 157 nCPM
  • extravillous trophoblasts: 132 nCPM
  • myonuclei: 89 nCPM
  • migrating cytotrophoblasts: 88 nCPM
  • syncytiotrophoblasts: 88 nCPM

Immune cell

  • basophil: 12 nTPM
  • plasmacytoid DC: 9.6 nTPM
  • eosinophil: 8.6 nTPM
  • memory B-cell: 7 nTPM
  • memory CD4 T-cell: 6.4 nTPM
  • memory CD8 T-cell: 6.3 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • white matter: 21 nTPM
  • cerebellum: 20 nTPM
  • midbrain: 20 nTPM
  • cerebral cortex: 20 nTPM
  • thalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC30A5.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.07
gnomAD missense Z
2.01
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A5 as an antibody target. Whether an autoantibody or antibody against SLC30A5 could matter depends on whether native SLC30A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A5 is annotated at the cell surface, where native SLC30A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC30A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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