Seroatlas · Human Serome Atlas

DCTD

Deoxycytidylate deaminase

Also known as: DCTD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P32321
Gene: DCTD
Ensembl: ENSG00000129187
Chromosome: 4
Canonical length: 178 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homohexamer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>P32321|DCTD
     1  MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG IGYNGMPNGC
    61  SDDVLPWRRT AENKLDTKYP YVCHAELNAI MNKNSTDVKG CSMYVALFPC NECAKLIIQA
   121  GIKEVIFMSD KYHDSDEATA ARLLFNMAGV TFRKFIPKCS KIVIDFDSIN SRPSQKLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCTD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 94 nTPM
adrenal gland: 80 nTPM
liver: 75 nTPM
choroid plexus: 74 nTPM
ovary: 65 nTPM
esophagus: 59 nTPM

Single-cell type

esophageal suprabasal cells: 114 nCPM
esophageal basal cells: 100 nCPM
parietal cells: 96 nCPM
adrenal cortex cells: 84 nCPM
esophageal apical cells: 84 nCPM
gastric chief cells: 82 nCPM

Immune cell

MAIT T-cell: 77 nTPM
NK-cell: 74 nTPM
memory B-cell: 71 nTPM
basophil: 69 nTPM
memory CD8 T-cell: 63 nTPM
gdT-cell: 61 nTPM

Brain region

choroid plexus: 64 nTPM
white matter: 52 nTPM
spinal cord: 49 nTPM
hypothalamus: 49 nTPM
midbrain: 47 nTPM
medulla oblongata: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCTD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCTD as an antibody target. Whether an autoantibody or antibody against DCTD could matter depends on whether native DCTD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCTD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCTD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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