Seroatlas · Human Serome Atlas

BET1

BET1 homolog

Also known as: BET1_HUMAN, hbet1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15155
Gene
BET1
Ensembl
ENSG00000105829
Chromosome
7
Canonical length
118 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>O15155|BET1
     1  MRRAGLGEGV PPGNYGNYGY ANSGYSACEE ENERLTESLR SKVTAIKSLS IEIGHEVKTQ
    61  NKLLAEMDSQ FDSTTGFLGK TMGKLKILSR GSQTKLLCYM MLFSLFVFFI IYWIIKLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BET1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 34 nTPM
  • epididymis: 32 nTPM
  • liver: 30 nTPM
  • adrenal gland: 27 nTPM
  • ovary: 26 nTPM
  • salivary gland: 25 nTPM

Single-cell type

  • extravillous trophoblasts: 261 nCPM
  • syncytiotrophoblasts: 164 nCPM
  • epididymal principal cells: 153 nCPM
  • lactotrophs: 152 nCPM
  • migrating cytotrophoblasts: 115 nCPM
  • breast lactating cells: 99 nCPM

Immune cell

  • basophil: 63 nTPM
  • memory B-cell: 41 nTPM
  • plasmacytoid DC: 40 nTPM
  • naive B-cell: 38 nTPM
  • naive CD4 T-cell: 27 nTPM
  • MAIT T-cell: 26 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 15 nTPM
  • medulla oblongata: 12 nTPM
  • midbrain: 12 nTPM
  • spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BET1.

Disease | AllUniProt

Conditions BET1 is implicated in, by any mechanism.

  • Muscular dystrophy, congenital, with rapid progression (MDRP) MIM:254100

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 19 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Muscular dystrophy, congenital, with rapid progression

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BET1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BET1 as an antibody target. Whether an autoantibody or antibody against BET1 could matter depends on whether native BET1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BET1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BET1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BET1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...