Seroatlas · Human Serome Atlas

TMED7

Transmembrane emp24 domain-containing protein 7

Also known as: CGI-109, FLJ90481, p24g3, p24gamma3, TMED7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B3
Gene: TMED7
Ensembl: ENSG00000134970
Chromosome: 5
Canonical length: 224 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9Y3B3|TMED7
     1  MPRPGSAQRW AAVAGRWGCR LLALLLLVPG PGGASEITFE LPDNAKQCFY EDIAQGTKCT
    61  LEFQVITGGH YDVDCRLEDP DGKVLYKEMK KQYDSFTFTA SKNGTYKFCF SNEFSTFTHK
   121  TVYFDFQVGE DPPLFPSENR VSALTQMESA CVSIHEALKS VIDYQTHFRL REAQGRSRAE
   181  DLNTRVAYWS VGEALILLVV SIGQVFLLKS FFSDKRTTTT RVGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

liver: 75 nTPM
thyroid gland: 75 nTPM
epididymis: 66 nTPM
kidney: 51 nTPM
parathyroid gland: 50 nTPM
cervix: 48 nTPM

Single-cell type

oligodendrocytes: 62 nCPM
oligodendrocyte progenitor cells: 42 nCPM
ependymal cells: 38 nCPM
microglia: 33 nCPM
other brain neurons: 31 nCPM
brain inhibitory neurons: 25 nCPM

Immune cell

basophil: 26 nTPM
classical monocyte: 24 nTPM
intermediate monocyte: 23 nTPM
total PBMC: 21 nTPM
eosinophil: 20 nTPM
myeloid DC: 19 nTPM

Brain region

white matter: 94 nTPM
medulla oblongata: 84 nTPM
choroid plexus: 79 nTPM
spinal cord: 70 nTPM
cerebellum: 65 nTPM
basal ganglia: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.48
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMED7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED7 as an antibody target. Whether an autoantibody or antibody against TMED7 could matter depends on whether native TMED7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMED7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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