Seroatlas · Human Serome Atlas

SLC30A6

Zinc transporter 6

Also known as: FLJ31101, ZNT6, ZNT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NXT4
Gene
SLC30A6
Ensembl
ENSG00000152683
Chromosome
2
Canonical length
461 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q6NXT4|SLC30A6
     1  MGTIHLFRKP QRSFFGKLLR EFRLVAADRR SWKILLFGVI NLICTGFLLM WCSSTNSIAL
    61  TAYTYLTIFD LFSLMTCLIS YWVTLRKPSP VYSFGFERLE VLAVFASTVL AQLGALFILK
   121  ESAERFLEQP EIHTGRLLVG TFVALCFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS
   181  RSLCGIIPGL SSIFLPRMNP FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF
   241  GTMYPMSVYS GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH
   301  VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPA LLSGPVAANV LNFSDHHVIP
   361  MPLLKGTDDL NPVTSTPAKP SSPPPEFSFN TPGKNVNPVI LLNTQTRPYG FGLNHGHTPY
   421  SSMLNQGLGV PGIGATQGLR TGFTNIPSRY GTNNRIGQPR P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 11 nTPM
  • thyroid gland: 11 nTPM
  • kidney: 11 nTPM
  • parathyroid gland: 11 nTPM
  • liver: 10 nTPM
  • pancreas: 9.8 nTPM

Single-cell type

  • myonuclei: 108 nCPM
  • neutrophil progenitors: 67 nCPM
  • somatotrophs: 66 nCPM
  • syncytiotrophoblasts: 64 nCPM
  • adipocytes: 63 nCPM
  • lactotrophs: 61 nCPM

Immune cell

  • basophil: 13 nTPM
  • NK-cell: 7 nTPM
  • T-reg: 4.6 nTPM
  • MAIT T-cell: 3.5 nTPM
  • naive CD4 T-cell: 3.4 nTPM
  • naive CD8 T-cell: 3.2 nTPM

Brain region

  • white matter: 16 nTPM
  • cerebellum: 14 nTPM
  • choroid plexus: 14 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 14 nTPM
  • pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A6 as an antibody target. Whether an autoantibody or antibody against SLC30A6 could matter depends on whether native SLC30A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC30A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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