Seroatlas · Human Serome Atlas

DRC12

Dynein regulatory complex protein 12

Also known as: CCDC153, DRC12_HUMAN, LOC283152

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q494R4
Gene: DRC12
Ensembl: ENSG00000248712
Chromosome: 11
Canonical length: 210 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q494R4|DRC12
     1  MPPKNKEKGK KSGAQKKKKN WGADVVAESR HRLVVLEKEL LRDHLALRRD EARRAKASED
    61  QLRQRLQGVE AELEGARSEG KAIYAEMSRQ CHALQEDMQT RSKQLEEEVK GLRGQLEACQ
   121  REAAAAREEA EQALGERDQA LAQLRAHMAD MEAKYEEILH DSLDRLLAKL RAIKQQWDGA
   181  ALRLHARHKE QQRQFGLTPP GSLRPPAPSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 23 nTPM
fallopian tube: 23 nTPM
pituitary gland: 7.1 nTPM
parathyroid gland: 5.1 nTPM
hypothalamus: 3.8 nTPM
testis: 3.3 nTPM

Single-cell type

fallopian tube ciliated cells: 257 nCPM
respiratory ciliated cells: 257 nCPM
epididymal efferent duct ciliated cells: 243 nCPM
endometrial ciliated cells: 112 nCPM
ependymal cells: 48 nCPM
oocytes: 14 nCPM

Immune cell

neutrophil: 24 nTPM
eosinophil: 5.6 nTPM
classical monocyte: 2.8 nTPM
myeloid DC: 1.9 nTPM
plasmacytoid DC: 1.9 nTPM
non-classical monocyte: 1.8 nTPM

Brain region

choroid plexus: 7.6 nTPM
midbrain: 7 nTPM
cerebellum: 6.9 nTPM
medulla oblongata: 6.8 nTPM
hypothalamus: 6 nTPM
cerebral cortex: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

Dynein regulatory complex protein 12-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GORASP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRC12 as an antibody target. Whether an autoantibody or antibody against DRC12 could matter depends on whether native DRC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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