DPYSL2

Protein identityUniProt · HPA

UniProt accession

Q16555

Gene

DPYSL2

Ensembl

ENSG00000092964

Chromosome

8

Canonical length

572 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Microtubules,Mitotic spindle,Primary cilium,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q16555|DPYSL2
     1  MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA
    61  HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF
   121  DQWREWADSK SCCDYSLHVD ISEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ
   181  IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI
   241  TIANQTNCPL YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA
   301  FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE
   361  RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR IAVGSDADLV IWDPDSVKTI
   421  SAKTHNSSLE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK
   481  RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS
   541  LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPYSL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

231 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPYSL2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on DPYSL2 was assayed in.

• multiple sclerosis B cell

ReferencesPubMed · IEDB

Publications for DPYSL2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

0.99

gnomAD missense Z

3.88

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• cytoskeleton organization
• endocytosis
• nervous system development
• nucleobase-containing compound metabolic process
• signal transduction

Molecular functions

• dihydropyrimidinase activity
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
• identical protein binding

Cellular components

• cilium
• cytosol
• extracellular exosome
• microtubule cytoskeleton
• mitotic spindle
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Amidohydrolase-related
• Metal-dependent hydrolase, composite domain superfamily
• Hydantoinase/dihydropyrimidinase
• Metal-dependent hydrolase
• Metallo-dependent Hydrolases Superfamily
• Amidohydrolase family

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Developmental protein
• Differentiation
• Membrane
• Methylation
• Neurogenesis
• Phosphoprotein
• S-nitrosylation

InteractionsUniProt · HPA

Protein binding partners of DPYSL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLN6
• HTR4
• MICALL1
• SELENOW
• DPYSL5
• ARID1B
• CRMP1
• DPYSL3
• DPYSL4
• GORASP2