Seroatlas · Human Serome Atlas

GABARAPL2

Gamma-aminobutyric acid receptor-associated protein-like 2

Also known as: ATG8, ATG8C, GATE-16, GATE16, GBRL2_HUMAN, GEF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60520
Gene: GABARAPL2
Ensembl: ENSG00000034713
Chromosome: 16
Canonical length: 117 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables phosphatidylethanolamine binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of proteasomal protein catabolic process and protein localization to endoplasmic reticulum. Located in Golgi membrane and autophagosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P60520|GABARAPL2
     1  MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF
    61  MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABARAPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 398 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 398 nTPM
midbrain: 393 nTPM
hypothalamus: 360 nTPM
basal ganglia: 354 nTPM
amygdala: 346 nTPM
cerebral cortex: 337 nTPM

Single-cell type

esophageal apical cells: 1,142 nCPM
platelets: 692 nCPM
syncytiotrophoblasts: 491 nCPM
oocytes: 488 nCPM
neutrophils: 443 nCPM
parietal cells: 421 nCPM

Immune cell

neutrophil: 505 nTPM
eosinophil: 372 nTPM
basophil: 347 nTPM
plasmacytoid DC: 275 nTPM
total PBMC: 242 nTPM
memory B-cell: 216 nTPM

Brain region

white matter: 311 nTPM
spinal cord: 289 nTPM
cerebellum: 271 nTPM
hypothalamus: 270 nTPM
medulla oblongata: 258 nTPM
thalamus: 240 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABARAPL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABARAPL2 as an antibody target. Whether an autoantibody or antibody against GABARAPL2 could matter depends on whether native GABARAPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABARAPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GABARAPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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