Seroatlas · Human Serome Atlas

RETREG3

Reticulophagy regulator 3

Also known as: DKFZp686B1036, FAM134C, FLJ33806, RETR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VR2
Gene
RETREG3
Ensembl
ENSG00000141699
Chromosome
17
Canonical length
466 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Involved in endoplasmic reticulum tubular network organization; positive regulation of neuron projection development; and reticulophagy. Located in endoplasmic reticulum tubular network. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q86VR2|RETREG3
     1  MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE PLLSRVQAAL
    61  VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII VCIDQWKNKI WPEIKVPRPD
   121  ALDNESWGFV HPRLLSVPEL CHHVAEVWVS GTIFIRNVLL FKKQNPGKFC LLSCGILTFL
   181  AVLGRYVPGL LLSYLMLVTV MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE
   241  RQLRRRALHP ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
   301  NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS IGMPSLMYRS
   361  PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL VSQGMIQLAL SGASQPGPSG
   421  APAQRATRGF LRSPSSDLDT DAEGDDFELL DQSELSQLDP ASSRSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RETREG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 38 nTPM
  • testis: 37 nTPM
  • liver: 32 nTPM
  • skin: 32 nTPM
  • retina: 29 nTPM
  • spleen: 29 nTPM

Single-cell type

  • early spermatids: 180 nCPM
  • late spermatids: 144 nCPM
  • rod photoreceptor cells: 90 nCPM
  • cone photoreceptor cells: 87 nCPM
  • sertoli cells: 85 nCPM
  • esophageal apical cells: 81 nCPM

Immune cell

  • T-reg: 57 nTPM
  • basophil: 55 nTPM
  • gdT-cell: 45 nTPM
  • memory CD8 T-cell: 43 nTPM
  • naive CD8 T-cell: 41 nTPM
  • MAIT T-cell: 39 nTPM

Brain region

  • thalamus: 31 nTPM
  • choroid plexus: 29 nTPM
  • midbrain: 28 nTPM
  • pons: 27 nTPM
  • hypothalamus: 26 nTPM
  • amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.13
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RETREG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RETREG3 as an antibody target. Whether an autoantibody or antibody against RETREG3 could matter depends on whether native RETREG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RETREG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RETREG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RETREG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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