Seroatlas · Human Serome Atlas

BNIP3L

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Also known as: BNI3L_HUMAN, BNIP3a, Nix

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60238
Gene: BNIP3L
Ensembl: ENSG00000104765
Chromosome: 8
Canonical length: 219 aa
Protein class: Cancer-related genes, Predicted membrane proteins, Transporters
Subcellular location: Nuclear speckles,Mitochondria

OverviewNCBI Gene

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>O60238|BNIP3L
     1  MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV
    61  PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS
   121  EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI
   181  FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BNIP3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 182 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 182 nTPM
retina: 136 nTPM
adipose tissue: 122 nTPM
ovary: 119 nTPM
placenta: 98 nTPM
blood vessel: 80 nTPM

Single-cell type

esophageal apical cells: 916 nCPM
endometrial glandular cells: 868 nCPM
erythrocytes: 671 nCPM
müller glia: 473 nCPM
monocytes: 464 nCPM
neutrophils: 452 nCPM

Immune cell

neutrophil: 371 nTPM
basophil: 337 nTPM
classical monocyte: 299 nTPM
total PBMC: 239 nTPM
eosinophil: 184 nTPM
myeloid DC: 167 nTPM

Brain region

white matter: 170 nTPM
medulla oblongata: 137 nTPM
basal ganglia: 129 nTPM
cerebellum: 122 nTPM
midbrain: 120 nTPM
cerebral cortex: 118 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.15
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BNIP3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BNIP3L as an antibody target. Whether an autoantibody or antibody against BNIP3L could matter depends on whether native BNIP3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BNIP3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BNIP3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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