Seroatlas · Human Serome Atlas

BCL2L13

Bcl-2-like protein 13

Also known as: B2L13_HUMAN, BCL-RAMBO, MIL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXK5
Gene
BCL2L13
Ensembl
ENSG00000099968
Chromosome
22
Canonical length
485 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9BXK5|BCL2L13
     1  MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS LDQEILLKVK
    61  TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM EDCLAHLGEK VSQELKEPLH
   121  KALQMLLSQP VTYQAFRECT LETTVHASGW NKILVPLVLL RQMLLELTRR GQEPLSALLQ
   181  FGVTYLEDYS AEYIIQQGGW GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES
   241  PTVTTSWQSE SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN
   301  NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT ATSLLGTREP
   361  DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP ALEPTETLLS EKEINAREES
   421  LVEELSPASE KKPVPPSEGK SRLSPAGEMK PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL
   481  ALRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • retina: 41 nTPM
  • tongue: 38 nTPM
  • skeletal muscle: 37 nTPM
  • liver: 15 nTPM
  • heart muscle: 14 nTPM
  • parathyroid gland: 14 nTPM

Single-cell type

  • ocular epithelial cells: 471 nCPM
  • retinal bipolar cells: 330 nCPM
  • myonuclei: 305 nCPM
  • retinal ganglion cells: 232 nCPM
  • syncytiotrophoblasts: 179 nCPM
  • renal collecting duct intercalated cells: 177 nCPM

Immune cell

  • classical monocyte: 9.5 nTPM
  • intermediate monocyte: 8 nTPM
  • NK-cell: 6.5 nTPM
  • non-classical monocyte: 6.4 nTPM
  • myeloid DC: 5.4 nTPM
  • basophil: 5.1 nTPM

Brain region

  • midbrain: 45 nTPM
  • cerebral cortex: 41 nTPM
  • pons: 40 nTPM
  • medulla oblongata: 37 nTPM
  • thalamus: 36 nTPM
  • hypothalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L13 as an antibody target. Whether an autoantibody or antibody against BCL2L13 could matter depends on whether native BCL2L13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL2L13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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