Seroatlas · Human Serome Atlas

CALCOCO1

Calcium-binding and coiled-coil domain-containing protein 1

Also known as: CACO1_HUMAN, calphoglin, Cocoa, KIAA1536

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1Z2
Gene: CALCOCO1
Ensembl: ENSG00000012822
Chromosome: 12
Canonical length: 691 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; beta-catenin binding activity; and transcription coactivator activity. Involved in positive regulation of DNA-templated transcription and positive regulation of gene expression. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q9P1Z2|CALCOCO1
     1  MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI FKVEAACVRD
    61  YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE
   121  PRPMDELVTL EEADGGSDIL LVVPKATVLQ NQLDESQQER NDLMQLKLQL EGQVTELRSR
   181  VQELERALAT ARQEHTELME QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI
   241  SEKVLTKEVE LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL
   301  KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE LAASSQQKAT
   361  LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH LKEEKCQWSK ERAGLLQSVE
   421  AEKDKILKLS AEILRLEKAV QEERTQNQVF KTELAREKDS SLVQLSESKR ELTELRSALR
   481  VLQKEKEQLQ EEKQELLEYM RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE
   541  DESPEDMRLP PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE
   601  DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFTVGTL SETSTGGPAT PTWKECPICK
   661  ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALCOCO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 221 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 221 nTPM
blood vessel: 183 nTPM
skin: 165 nTPM
colon: 143 nTPM
cerebellum: 139 nTPM
heart muscle: 124 nTPM

Single-cell type

platelets: 112 nCPM
late spermatids: 103 nCPM
breast lactating cells: 96 nCPM
myonuclei: 90 nCPM
adipocytes: 83 nCPM
salivary acinar cells: 79 nCPM

Immune cell

basophil: 86 nTPM
eosinophil: 77 nTPM
neutrophil: 72 nTPM
T-reg: 34 nTPM
gdT-cell: 26 nTPM
non-classical monocyte: 24 nTPM

Brain region

choroid plexus: 83 nTPM
cerebellum: 79 nTPM
basal ganglia: 78 nTPM
white matter: 67 nTPM
pons: 67 nTPM
cerebral cortex: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALCOCO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALCOCO1 as an antibody target. Whether an autoantibody or antibody against CALCOCO1 could matter depends on whether native CALCOCO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALCOCO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALCOCO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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