Seroatlas · Human Serome Atlas

TP53INP2

Tumor protein p53-inducible nuclear protein 2

Also known as: C20orf110, dJ1181N3.1, DKFZp434B2411, DKFZp434O0827, DOR, FLJ21759, FLJ23500, PINH, T53I2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXH6
Gene: TP53INP2
Ensembl: ENSG00000078804
Chromosome: 20
Canonical length: 220 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q8IXH6|TP53INP2
     1  MFQRLSSLFF STPSPPEDPD CPRAFVSEED EVDGWLIIDL PDSYAAPPSP GAAPAPAGRP
    61  PPAPSLMDES WFVTPPACFT AEGPGLGPAR LQSSPLEDLL IEHPSMSVYV TGSTIVLEPG
   121  SPSPLPDAAL PDGDLSEGEL TPARREPRAA RHAAPLPARA ALLEKAGQVR RLQRARQRAE
   181  RHALSAKAVQ RQNRARESRP RRSKNQSSFI YQPCQRQFNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53INP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 888 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 888 nTPM
midbrain: 633 nTPM
hippocampal formation: 373 nTPM
hypothalamus: 308 nTPM
amygdala: 306 nTPM
basal ganglia: 300 nTPM

Single-cell type

late spermatids: 585 nCPM
esophageal apical cells: 326 nCPM
early spermatids: 261 nCPM
colonocytes: 117 nCPM
neutrophils: 103 nCPM
goblet cells: 85 nCPM

Immune cell

neutrophil: 2.7 nTPM
eosinophil: 0.6 nTPM
basophil: 0.5 nTPM
plasmacytoid DC: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 802 nTPM
white matter: 740 nTPM
pons: 707 nTPM
midbrain: 674 nTPM
basal ganglia: 656 nTPM
spinal cord: 634 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.81
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TP53INP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53INP2 as an antibody target. Whether an autoantibody or antibody against TP53INP2 could matter depends on whether native TP53INP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53INP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53INP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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