Seroatlas · Human Serome Atlas

IRGQ

Immunity-related GTPase family Q protein

Also known as: FKSG27, IRGQ_HUMAN, IRGQ1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WZA9
Gene
IRGQ
Ensembl
ENSG00000167378
Chromosome
19
Canonical length
623 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in positive regulation of autophagy; protein quality control for misfolded or incompletely synthesized proteins; and substrate localization to autophagosome. Is active in autophagosome and lysosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>Q8WZA9|IRGQ
     1  MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR AAGPGLFLGE
    61  LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA LAALARGTPL LAVRNLRPGD
   121  SQTAAQARDQ TAALLNSAGL GAADLFVLPA NCGSSDGCEE LERLRAALQS QAEALRRLLP
   181  PAQDGFEVLG AAELEAVREA FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD
   241  MLLGLDPGDP GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL
   301  ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK GESLKNAGGG
   361  GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM KKSGGGDSER AAALSPEDET
   421  WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL PPAQAGALLL ALPPASPSAA RTKAAALRAG
   481  AWRPALLASL AAAAAPLPGL GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE
   541  LAARAHFPGP VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV
   601  LLQALDEMRA DAEAVLAPPE PAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRGQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 14 nTPM
  • bone marrow: 12 nTPM
  • cerebral cortex: 10 nTPM
  • pituitary gland: 9.1 nTPM
  • skeletal muscle: 8.1 nTPM
  • heart muscle: 8 nTPM

Single-cell type

  • tuft cells: 12 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • late spermatids: 5 nCPM
  • hematopoietic stem cells: 4.9 nCPM
  • cardiomyocytes: 4.2 nCPM
  • cone photoreceptor cells: 4.1 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • classical monocyte: 0.9 nTPM
  • intermediate monocyte: 0.8 nTPM
  • non-classical monocyte: 0.8 nTPM
  • gdT-cell: 0.6 nTPM
  • myeloid DC: 0.6 nTPM

Brain region

  • thalamus: 42 nTPM
  • cerebral cortex: 40 nTPM
  • basal ganglia: 39 nTPM
  • pons: 38 nTPM
  • midbrain: 37 nTPM
  • hypothalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
1.64
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRGQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRGQ as an antibody target. Whether an autoantibody or antibody against IRGQ could matter depends on whether native IRGQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRGQ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRGQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRGQ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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