Seroatlas · Human Serome Atlas

TP53INP1

Tumor protein p53-inducible nuclear protein 1

Also known as: DKFZp434M1317, FLJ22139, P53DINP1, SIP, T53I1_HUMAN, Teap, TP53INP1A, TP53INP1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A56
Gene: TP53INP1
Ensembl: ENSG00000164938
Chromosome: 8
Canonical length: 240 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of DNA-templated transcription; and positive regulation of autophagy. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q96A56|TP53INP1
     1  MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE EEDISEESPT
    61  EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP PPCFTAGGLT TIKVETSPME
   121  NLLIEHPSMS VYAVHNSCPG LSEATRGTDE LHSPSSPRVE AQNEMGQHIH CYVAALAAHT
   181  TFLEQPKSFR PSQWIKEHSE RQPLNRNSLR RQNLTRDCHP RQVKHNGWVV HQPCPRQYNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53INP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

liver: 95 nTPM
pancreas: 57 nTPM
bone marrow: 40 nTPM
tonsil: 39 nTPM
spleen: 38 nTPM
lymph node: 34 nTPM

Single-cell type

plasma cells: 472 nCPM
thymocytes: 284 nCPM
hepatocytes: 230 nCPM
b-cells: 199 nCPM
neutrophils: 150 nCPM
pancreatic acinar cells: 141 nCPM

Immune cell

basophil: 55 nTPM
neutrophil: 17 nTPM
eosinophil: 12 nTPM
memory B-cell: 12 nTPM
naive B-cell: 9.7 nTPM
T-reg: 6.6 nTPM

Brain region

choroid plexus: 17 nTPM
white matter: 15 nTPM
medulla oblongata: 15 nTPM
thalamus: 13 nTPM
basal ganglia: 13 nTPM
spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

antioxidant activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TP53INP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53INP1 as an antibody target. Whether an autoantibody or antibody against TP53INP1 could matter depends on whether native TP53INP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53INP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53INP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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