Seroatlas · Human Serome Atlas

GOSR1

Golgi SNAP receptor complex member 1

Also known as: GOLIM2, GOS-28, GOS28, GOSR1_HUMAN, GS28, P28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95249
Gene: GOSR1
Ensembl: ENSG00000108587
Chromosome: 17
Canonical length: 250 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>O95249|GOSR1
     1  MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDRY SSDTTPLLNG
    61  SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL NAALMHTLQR HRDILQDYTH
   121  EFHKTKANFM AIRERENLMG SVRKDIESYK SGSGVNNRRT ELFLKEHDHL RNSDRLIEET
   181  ISIAMATKEN MTSQRGMLKS IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC
   241  TILLLLYAFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

liver: 29 nTPM
parathyroid gland: 27 nTPM
kidney: 23 nTPM
tonsil: 23 nTPM
thyroid gland: 23 nTPM
thymus: 23 nTPM

Single-cell type

late primary spermatocytes: 165 nCPM
myonuclei: 132 nCPM
somatotrophs: 130 nCPM
lactotrophs: 128 nCPM
adrenal medulla cells: 117 nCPM
corticotrophs: 112 nCPM

Immune cell

NK-cell: 36 nTPM
naive B-cell: 36 nTPM
MAIT T-cell: 35 nTPM
memory B-cell: 34 nTPM
naive CD4 T-cell: 34 nTPM
T-reg: 34 nTPM

Brain region

cerebellum: 31 nTPM
midbrain: 30 nTPM
thalamus: 29 nTPM
choroid plexus: 29 nTPM
cerebral cortex: 29 nTPM
medulla oblongata: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.06
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SNAP receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Snare region anchored in the vesicle membrane C-terminus
Golgi SNAP receptor complex, subunit 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOSR1 as an antibody target. Whether an autoantibody or antibody against GOSR1 could matter depends on whether native GOSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOSR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...