Seroatlas · Human Serome Atlas

ATG13

Autophagy-related protein 13

Also known as: ATG13_HUMAN, KIAA0652

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75143
Gene
ATG13
Ensembl
ENSG00000175224
Chromosome
11
Canonical length
517 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>O75143|ATG13
     1  METDLNSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW FNLAIKDIPE
    61  VTHEAKKALA GQLPAVGRSM CVEISLKTSE GDSMELEIWC LEMNEKCDKE IKVSYTVYNR
   121  LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI LYRIYFGEVQ LSGLGEGFQT VRVGTVGTPV
   181  GTITLSCAYR INLAFMSTRQ FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAGEDTGV
   241  IYPSVEDSQE VCTTSFSTSP PSQLSSSRLS YQPAALGVGS ADLAYPVVFA AGLNATHPHQ
   301  LMVPGKEGGV PLAPNQPVHG TQADQERLAT CTPSDRTHCA ATPSSSEDTE TVSNSSEGRA
   361  SPHDVLETIF VRKVGAFVNK PINQVTLTSL DIPFAMFAPK NLELEDTDPM VNPPDSPETE
   421  SPLQGSLHSD GSSGGSSGNT HDDFVMIDFK PAFSKDDILP MDLGTFYREF QNPPQLSSLS
   481  IDIGAQSMAE DLDSLPEKLA VHEKNVREFD AFVETLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • testis: 75 nTPM
  • bone marrow: 57 nTPM
  • pituitary gland: 55 nTPM
  • choroid plexus: 48 nTPM
  • retina: 44 nTPM
  • pancreas: 42 nTPM

Single-cell type

  • endometrial glandular cells: 187 nCPM
  • oligodendrocytes: 114 nCPM
  • endometrial ciliated cells: 112 nCPM
  • endometrial luminal cells: 105 nCPM
  • neutrophils: 99 nCPM
  • neutrophil progenitors: 98 nCPM

Immune cell

  • neutrophil: 68 nTPM
  • eosinophil: 49 nTPM
  • T-reg: 45 nTPM
  • intermediate monocyte: 43 nTPM
  • basophil: 42 nTPM
  • total PBMC: 40 nTPM

Brain region

  • white matter: 177 nTPM
  • cerebral cortex: 143 nTPM
  • basal ganglia: 140 nTPM
  • pons: 129 nTPM
  • medulla oblongata: 128 nTPM
  • midbrain: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.52
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • HORMA domain superfamily
  • Autophagy-related protein 13, N-terminal
  • Autophagy-related protein 13
  • Autophagy-related protein 13

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG13 as an antibody target. Whether an autoantibody or antibody against ATG13 could matter depends on whether native ATG13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATG13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...