Seroatlas · Human Serome Atlas

TBC1D5

TBC1 domain family member 5

Also known as: KIAA0210, TBCD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92609
Gene: TBC1D5
Ensembl: ENSG00000131374
Chromosome: 3
Canonical length: 795 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

795 residues, UniProt reviewed canonical sequence.

>Q92609|TBC1D5
     1  MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG TFNSYRKEWE
    61  ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ DKSQWISRIE ELRAWYSNIK
   121  EIHITNPRKV VGQQDLMINN PLSQDEGSLW NKFFQDKELR SMIEQDVKRT FPEMQFFQQE
   181  NVRKILTDVL FCYARENEQL LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV
   241  LNPEYLEHDA YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK
   301  VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV VWDALFADGL
   361  SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD VHSLILKALF LRDPKRNPRP
   421  VTYQFHPNLD YYKARGADLM NKSRTNAKGA PLNINKVSNS LINFGRKLIS PAMAPGSAGG
   481  PVPGGNSSSS SSVVIPTRTS AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP
   541  SVESLPGGRE FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN
   601  DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK GSLRFNQSQL
   661  EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS SETPGCTDRG NSDDFILISK
   721  DDDGSSARGS FSGQAQPLRT LRSTSGKSQA PVCSPLVFSD PLMGPASASS SNPSSSPDDD
   781  SSKDSGFTIV SPLDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 27 nTPM
parathyroid gland: 26 nTPM
bone marrow: 23 nTPM
spleen: 23 nTPM
cerebral cortex: 23 nTPM
ovary: 23 nTPM

Single-cell type

thyrotrophs: 1,315 nCPM
lactotrophs: 1,098 nCPM
neutrophil progenitors: 995 nCPM
microglia: 891 nCPM
somatotrophs: 828 nCPM
neutrophils: 807 nCPM

Immune cell

basophil: 12 nTPM
eosinophil: 11 nTPM
naive B-cell: 11 nTPM
neutrophil: 10 nTPM
memory B-cell: 9.2 nTPM
myeloid DC: 8.5 nTPM

Brain region

white matter: 84 nTPM
medulla oblongata: 72 nTPM
basal ganglia: 68 nTPM
spinal cord: 64 nTPM
midbrain: 63 nTPM
cerebellum: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D5 as an antibody target. Whether an autoantibody or antibody against TBC1D5 could matter depends on whether native TBC1D5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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