Seroatlas · Human Serome Atlas

NCOA4

Nuclear receptor coactivator 4

Also known as: ARA70, DKFZp762E1112, ELE1, NCOA4_HUMAN, PTC3, RFG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13772
Gene
NCOA4
Ensembl
ENSG00000266412
Chromosome
10
Canonical length
614 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q13772|NCOA4
     1  MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA QIHSCISRHL
    61  ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN CLTHQLECTQ NKDLANQVSV
   121  CLERLGSLTL KPEDSTVLLF EADTITLRQT ITTFGSLKTI QIPEHLMAHA SSANIGPFLE
   181  KRGCISMPEQ KSASGIVAVP FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS
   241  SRACNFFNNV GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD
   301  LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC QGNQPKGVEI
   361  ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV EEVCRANEPC TSFAECVCDE
   421  NCEKEALYKW LLKKEGKDKN GMPVEPKPEP EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS
   481  RIADSFQVIK NSPLSEWLIR PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV
   541  LPGKKMGNLS QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK
   601  VDKEKWLYRT PLQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCOA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
349 nTPM

Expression across tissuesHPA

Tissue

  • liver: 349 nTPM
  • duodenum: 235 nTPM
  • tongue: 181 nTPM
  • bone marrow: 179 nTPM
  • skeletal muscle: 153 nTPM
  • kidney: 149 nTPM

Single-cell type

  • platelets: 1,776 nCPM
  • megakaryocytes: 464 nCPM
  • kupffer cells: 463 nCPM
  • neutrophils: 364 nCPM
  • hofbauer cells: 335 nCPM
  • erythrocytes: 333 nCPM

Immune cell

  • neutrophil: 843 nTPM
  • basophil: 694 nTPM
  • eosinophil: 613 nTPM
  • total PBMC: 559 nTPM
  • classical monocyte: 364 nTPM
  • non-classical monocyte: 277 nTPM

Brain region

  • white matter: 107 nTPM
  • cerebellum: 98 nTPM
  • hypothalamus: 98 nTPM
  • midbrain: 95 nTPM
  • pons: 93 nTPM
  • medulla oblongata: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
0.77
DepMap mean gene effect
-0.43
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nuclear receptor coactivator 4, N-terminal
  • Nuclear receptor coactivator 4
  • Nuclear coactivator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCOA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCOA4 as an antibody target. Whether an autoantibody or antibody against NCOA4 could matter depends on whether native NCOA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCOA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCOA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCOA4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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