Seroatlas · Human Serome Atlas

UBA5

Ubiquitin-like modifier-activating enzyme 5

Also known as: FLJ23251, UBA5_HUMAN, UBE1DC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZZ9
Gene
UBA5
Ensembl
ENSG00000081307
Chromosome
3
Canonical length
404 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>Q9GZZ9|UBA5
     1  MAESVERLQQ RVQELERELA QERSLQVPRS GDGGGGRVRI EKMSSEVVDS NPYSRLMALK
    61  RMGIVSDYEK IRTFAVAIVG VGGVGSVTAE MLTRCGIGKL LLFDYDKVEL ANMNRLFFQP
   121  HQAGLSKVQA AEHTLRNINP DVLFEVHNYN ITTVENFQHF MDRISNGGLE EGKPVDLVLS
   181  CVDNFEARMT INTACNELGQ TWMESGVSEN AVSGHIQLII PGESACFACA PPLVVAANID
   241  EKTLKREGVC AASLPTTMGV VAGILVQNVL KFLLNFGTVS FYLGYNAMQD FFPTMSMKPN
   301  PQCDDRNCRK QQEEYKKKVA ALPKQEVIQE EEEIIHEDNE WGIELVSEVS EEELKNFSGP
   361  VPDLPEGITV AYTIPKKQED SVTELTVEDS GESLEDLMAK MKNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 49 nTPM
  • salivary gland: 45 nTPM
  • liver: 30 nTPM
  • thyroid gland: 30 nTPM
  • skeletal muscle: 29 nTPM
  • kidney: 29 nTPM

Single-cell type

  • late spermatids: 735 nCPM
  • cardiomyocytes: 260 nCPM
  • early spermatids: 170 nCPM
  • breast lactating cells: 164 nCPM
  • syncytiotrophoblasts: 146 nCPM
  • choroid plexus epithelial cells: 134 nCPM

Immune cell

  • NK-cell: 26 nTPM
  • plasmacytoid DC: 19 nTPM
  • memory CD8 T-cell: 19 nTPM
  • naive CD8 T-cell: 16 nTPM
  • naive CD4 T-cell: 16 nTPM
  • myeloid DC: 16 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • basal ganglia: 35 nTPM
  • cerebral cortex: 34 nTPM
  • white matter: 33 nTPM
  • hypothalamus: 32 nTPM
  • cerebellum: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBA5.

Disease | AllUniProt

Conditions UBA5 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 44 (DEE44) MIM:617132
  • Spinocerebellar ataxia, autosomal recessive, 24 (SCAR24) MIM:617133

Disease | GeneticClinVar

40 pathogenic / likely-pathogenic of 290 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
1.29
DepMap mean gene effect
-0.53
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBA5 as an antibody target. Whether an autoantibody or antibody against UBA5 could matter depends on whether native UBA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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